Synthetic biology to access and expand nature's chemical diversity
Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of complex molecules with diverse applications, from medicine to agriculture and materials. Accessing these natural products promises to reinvigorate drug discovery pipelines and provide novel routes to synthesize c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/107490 https://orcid.org/0000-0003-0844-4776 |
| _version_ | 1811071482238861312 |
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| author | Smanski, Michael J. Zhou, Hui Claesen, Jan Shen, Ben Fischbach, Michael A. Voigt, Christopher A. |
| author2 | MIT Synthetic Biology Center |
| author_facet | MIT Synthetic Biology Center Smanski, Michael J. Zhou, Hui Claesen, Jan Shen, Ben Fischbach, Michael A. Voigt, Christopher A. |
| author_sort | Smanski, Michael J. |
| collection | MIT |
| description | Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of complex molecules with diverse applications, from medicine to agriculture and materials. Accessing these natural products promises to reinvigorate drug discovery pipelines and provide novel routes to synthesize complex chemicals. The pathways leading to the production of these molecules often comprise dozens of genes spanning large areas of the genome and are controlled by complex regulatory networks with some of the most interesting molecules being produced by non-model organisms. In this Review, we discuss how advances in synthetic biology — including novel DNA construction technologies, the use of genetic parts for the precise control of expression and for synthetic regulatory circuits — and multiplexed genome engineering can be used to optimize the design and synthesis of pathways that produce natural products. |
| first_indexed | 2024-09-23T08:51:49Z |
| format | Article |
| id | mit-1721.1/107490 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:51:49Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1074902022-09-30T11:48:11Z Synthetic biology to access and expand nature's chemical diversity Smanski, Michael J. Zhou, Hui Claesen, Jan Shen, Ben Fischbach, Michael A. Voigt, Christopher A. MIT Synthetic Biology Center Massachusetts Institute of Technology. Department of Biological Engineering Zhou, Hui Smanski, Michael J. Voigt, Christopher A. Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of complex molecules with diverse applications, from medicine to agriculture and materials. Accessing these natural products promises to reinvigorate drug discovery pipelines and provide novel routes to synthesize complex chemicals. The pathways leading to the production of these molecules often comprise dozens of genes spanning large areas of the genome and are controlled by complex regulatory networks with some of the most interesting molecules being produced by non-model organisms. In this Review, we discuss how advances in synthetic biology — including novel DNA construction technologies, the use of genetic parts for the precise control of expression and for synthetic regulatory circuits — and multiplexed genome engineering can be used to optimize the design and synthesis of pathways that produce natural products. 2017-03-20T14:32:54Z 2017-03-20T14:32:54Z 2016-02 Article http://purl.org/eprint/type/JournalArticle 1740-1526 1740-1534 http://hdl.handle.net/1721.1/107490 Smanski, Michael J. et al. “Synthetic Biology to Access and Expand Nature’s Chemical Diversity.” Nature Reviews Microbiology 14.3 (2016): 135–149. https://orcid.org/0000-0003-0844-4776 en_US http://dx.doi.org/10.1038/nrmicro.2015.24 Nature Reviews Microbiology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Smanski, Michael J. Zhou, Hui Claesen, Jan Shen, Ben Fischbach, Michael A. Voigt, Christopher A. Synthetic biology to access and expand nature's chemical diversity |
| title | Synthetic biology to access and expand nature's chemical diversity |
| title_full | Synthetic biology to access and expand nature's chemical diversity |
| title_fullStr | Synthetic biology to access and expand nature's chemical diversity |
| title_full_unstemmed | Synthetic biology to access and expand nature's chemical diversity |
| title_short | Synthetic biology to access and expand nature's chemical diversity |
| title_sort | synthetic biology to access and expand nature s chemical diversity |
| url | http://hdl.handle.net/1721.1/107490 https://orcid.org/0000-0003-0844-4776 |
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