CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery
The activation of T lymphocytes (T cells) requires signaling through the T-cell receptor (TCR). The role of the coreceptor molecules, CD4 and CD8, is not clear, although they are thought to augment TCR signaling by stabilizing interactions between the TCR and peptide–major histocompatibility (pMHC)...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2017
|
| Online Access: | http://hdl.handle.net/1721.1/107641 https://orcid.org/0000-0003-1268-9602 https://orcid.org/0000-0001-8253-7714 |