Poised chromatin in the mammalian germ line
Poised (bivalent) chromatin is defined by the simultaneous presence of histone modifications associated with both gene activation and repression. This epigenetic feature was first observed at promoters of lineage-specific regulatory genes in embryonic stem cells in culture. More recent work has show...
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| Format: | Article |
| Language: | en_US |
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Company of Biologists
2017
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| Online Access: | http://hdl.handle.net/1721.1/107653 https://orcid.org/0000-0001-9920-3411 |
| _version_ | 1826216832804061184 |
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| author | Lesch, B. J. Page, David C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Lesch, B. J. Page, David C |
| author_sort | Lesch, B. J. |
| collection | MIT |
| description | Poised (bivalent) chromatin is defined by the simultaneous presence of histone modifications associated with both gene activation and repression. This epigenetic feature was first observed at promoters of lineage-specific regulatory genes in embryonic stem cells in culture. More recent work has shown that, in vivo, mammalian germ cells maintain poised chromatin at promoters of many genes that regulate somatic development, and that they retain this state from fetal stages through meiosis and gametogenesis. We hypothesize that the poised chromatin state is essential for germ cell identity and function. We propose three roles for poised chromatin in the mammalian germ line: prevention of DNA methylation, maintenance of germ cell identity and preparation for totipotency. We discuss these roles in the context of recently proposed models for germline potency and epigenetic inheritance. |
| first_indexed | 2024-09-23T16:53:50Z |
| format | Article |
| id | mit-1721.1/107653 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:53:50Z |
| publishDate | 2017 |
| publisher | Company of Biologists |
| record_format | dspace |
| spelling | mit-1721.1/1076532022-09-29T22:16:27Z Poised chromatin in the mammalian germ line Lesch, B. J. Page, David C Massachusetts Institute of Technology. Department of Biology Page, David Page, David C Poised (bivalent) chromatin is defined by the simultaneous presence of histone modifications associated with both gene activation and repression. This epigenetic feature was first observed at promoters of lineage-specific regulatory genes in embryonic stem cells in culture. More recent work has shown that, in vivo, mammalian germ cells maintain poised chromatin at promoters of many genes that regulate somatic development, and that they retain this state from fetal stages through meiosis and gametogenesis. We hypothesize that the poised chromatin state is essential for germ cell identity and function. We propose three roles for poised chromatin in the mammalian germ line: prevention of DNA methylation, maintenance of germ cell identity and preparation for totipotency. We discuss these roles in the context of recently proposed models for germline potency and epigenetic inheritance. Howard Hughes Medical Institute National Institutes of Health (U.S.) 2017-03-22T19:22:14Z 2017-03-22T19:22:14Z 2014-09 Article http://purl.org/eprint/type/JournalArticle 0950-1991 1477-9129 http://hdl.handle.net/1721.1/107653 Lesch, B. J., and D. C. Page. “Poised Chromatin in the Mammalian Germ Line.” Development 141.19 (2014): 3619–3626. https://orcid.org/0000-0001-9920-3411 en_US http://dx.doi.org/10.1242/dev.113027 Development Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Company of Biologists Prof. Page via Courtney Crummett |
| spellingShingle | Lesch, B. J. Page, David C Poised chromatin in the mammalian germ line |
| title | Poised chromatin in the mammalian germ line |
| title_full | Poised chromatin in the mammalian germ line |
| title_fullStr | Poised chromatin in the mammalian germ line |
| title_full_unstemmed | Poised chromatin in the mammalian germ line |
| title_short | Poised chromatin in the mammalian germ line |
| title_sort | poised chromatin in the mammalian germ line |
| url | http://hdl.handle.net/1721.1/107653 https://orcid.org/0000-0001-9920-3411 |
| work_keys_str_mv | AT leschbj poisedchromatininthemammaliangermline AT pagedavidc poisedchromatininthemammaliangermline |