Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy
The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to delayed activation of mucosal dendritic cells (DCs), and subsequent delay in antigen present...
Main Authors: | Griffiths, Kristin L., Ahmed, Mushtaq, Das, Shibali, Gopal, Radha, Horne, William, Connell, Terry D., Kolls, Jay K., Artyomov, Maxim N., Rangel-Moreno, Javier, Khader, Shabaana A., Moynihan, Kelly Dare, Irvine, Darrell J |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Springer Nature
2017
|
Online Access: | http://hdl.handle.net/1721.1/107719 |
Similar Items
-
Overcoming dendritic cell-mediated suppression of T cell responses in a prostate tumor environment
by: Higham, Eileen M
Published: (2011) -
Identifying and overcoming performance bottlenecks in modern console hardware
by: Tan, Brian Kian How
Published: (2015) -
Roles for Innate Immunity in Combination Immunotherapies
by: Moynihan, Kelly Dare, et al.
Published: (2018) -
Engineering immunity : enhancing T Cell vaccines and combination immunotherapies for the treatment of cancer
by: Moynihan, Kelly D. (Kelly Dare)
Published: (2018) -
High-throughput quantitation of inorganic nanoparticle biodistribution at the single-cell level using mass cytometry
by: Bekdemir, Ahmet, et al.
Published: (2017)