A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion
Biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) coating for applications in drug-eluting stents has been receiving increasing interest as a result of its unique properties compared with biodurable polymers in delivering drug for reducing stents-related side effects. In this work, a mathematic...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
John Wiley & Sons, Inc.
2017
|
| Online Access: | http://hdl.handle.net/1721.1/107739 https://orcid.org/0000-0002-0109-3515 https://orcid.org/0000-0003-4304-3484 |
| _version_ | 1811068762507444224 |
|---|---|
| author | Zhu, Xiaoxiang Braatz, Richard D |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Zhu, Xiaoxiang Braatz, Richard D |
| author_sort | Zhu, Xiaoxiang |
| collection | MIT |
| description | Biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) coating for applications in drug-eluting stents has been receiving increasing interest as a result of its unique properties compared with biodurable polymers in delivering drug for reducing stents-related side effects. In this work, a mathematical model for describing the PLGA degradation and erosion and coupled drug release from PLGA stent coating is developed and validated. An analytical expression is derived for PLGA mass loss that predicts multiple experimental studies in the literature. An analytical model for the change of the number-average degree of polymerization [or molecular weight (MW)] is also derived. The drug transport model incorporates simultaneous drug diffusion through both the polymer solid and the liquid-filled pores in the coating, where an effective drug diffusivity model is derived taking into account factors including polymer MW change, stent coating porosity change, and drug partitioning between solid and aqueous phases. The model is used to describe in vitro sirolimus release from PLGA stent coating, and demonstrates the significance of simultaneous sirolimus release via diffusion through both polymer solid and pore space. The proposed model is compared to existing drug transport models, and the impact of model parameters, limitations and possible extensions of the model are also discussed. |
| first_indexed | 2024-09-23T08:00:46Z |
| format | Article |
| id | mit-1721.1/107739 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:00:46Z |
| publishDate | 2017 |
| publisher | John Wiley & Sons, Inc. |
| record_format | dspace |
| spelling | mit-1721.1/1077392022-09-23T10:17:26Z A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion Zhu, Xiaoxiang Braatz, Richard D Massachusetts Institute of Technology. Department of Chemical Engineering Zhu, Xiaoxiang Braatz, Richard D Biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) coating for applications in drug-eluting stents has been receiving increasing interest as a result of its unique properties compared with biodurable polymers in delivering drug for reducing stents-related side effects. In this work, a mathematical model for describing the PLGA degradation and erosion and coupled drug release from PLGA stent coating is developed and validated. An analytical expression is derived for PLGA mass loss that predicts multiple experimental studies in the literature. An analytical model for the change of the number-average degree of polymerization [or molecular weight (MW)] is also derived. The drug transport model incorporates simultaneous drug diffusion through both the polymer solid and the liquid-filled pores in the coating, where an effective drug diffusivity model is derived taking into account factors including polymer MW change, stent coating porosity change, and drug partitioning between solid and aqueous phases. The model is used to describe in vitro sirolimus release from PLGA stent coating, and demonstrates the significance of simultaneous sirolimus release via diffusion through both polymer solid and pore space. The proposed model is compared to existing drug transport models, and the impact of model parameters, limitations and possible extensions of the model are also discussed. National Institute for Biomedical Imaging and Bioengineering (U.S.) (NIBIB, contract grant number: 5RO1EB005181) 2017-03-27T20:44:34Z 2017-03-27T20:44:34Z 2015-05 2014-10 Article http://purl.org/eprint/type/JournalArticle 15493296 http://hdl.handle.net/1721.1/107739 Zhu, Xiaoxiang, and Richard D. Braatz. “A Mechanistic Model for Drug Release in PLGA Biodegradable Stent Coatings Coupled with Polymer Degradation and Erosion.” Journal of Biomedical Materials Research Part A 103, no. 7 (November 12, 2014): 2269–2279. https://orcid.org/0000-0002-0109-3515 https://orcid.org/0000-0003-4304-3484 en_US http://dx.doi.org/10.1002/jbm.a.35357 Journal of Biomedical Materials Research Part A Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf John Wiley & Sons, Inc. PMC |
| spellingShingle | Zhu, Xiaoxiang Braatz, Richard D A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion |
| title | A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion |
| title_full | A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion |
| title_fullStr | A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion |
| title_full_unstemmed | A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion |
| title_short | A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion |
| title_sort | mechanistic model for drug release in plga biodegradable stent coatings coupled with polymer degradation and erosion |
| url | http://hdl.handle.net/1721.1/107739 https://orcid.org/0000-0002-0109-3515 https://orcid.org/0000-0003-4304-3484 |
| work_keys_str_mv | AT zhuxiaoxiang amechanisticmodelfordrugreleaseinplgabiodegradablestentcoatingscoupledwithpolymerdegradationanderosion AT braatzrichardd amechanisticmodelfordrugreleaseinplgabiodegradablestentcoatingscoupledwithpolymerdegradationanderosion AT zhuxiaoxiang mechanisticmodelfordrugreleaseinplgabiodegradablestentcoatingscoupledwithpolymerdegradationanderosion AT braatzrichardd mechanisticmodelfordrugreleaseinplgabiodegradablestentcoatingscoupledwithpolymerdegradationanderosion |