Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies
Objective: To determine whether atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men. Design: Meta-analysis of cohort studies. Data: sources Studies published between January 1966 and March 2015, identified through a systematic search of Med...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en_US |
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BMJ Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/107757 https://orcid.org/0000-0002-6609-8712 |
| _version_ | 1826212788928774144 |
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| author | Emdin, Connor A Wong, Christopher X Altman, Douglas G Peters, Sanne AE Woodward, Mark Odutayo, Ayodele A Hsiao, Allan |
| author2 | Massachusetts Institute of Technology. Department of Economics |
| author_facet | Massachusetts Institute of Technology. Department of Economics Emdin, Connor A Wong, Christopher X Altman, Douglas G Peters, Sanne AE Woodward, Mark Odutayo, Ayodele A Hsiao, Allan |
| author_sort | Emdin, Connor A |
| collection | MIT |
| description | Objective: To determine whether atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men.
Design: Meta-analysis of cohort studies.
Data: sources Studies published between January 1966 and March 2015, identified through a systematic search of Medline and Embase and review of references.
Eligibility for selecting studies: Cohort studies with a minimum of 50 participants with and 50 without atrial fibrillation that reported sex specific associations between atrial fibrillation and all cause mortality, cardiovascular mortality, stroke, cardiac events (cardiac death and non-fatal myocardial infarction), and heart failure.
Data extraction: Two independent reviewers extracted study characteristics and maximally adjusted sex specific relative risks. Inverse variance weighted random effects meta-analysis was used to pool sex specific relative risks and their ratio.
Results: 30 studies with 4 371 714 participants were identified. Atrial fibrillation was associated with a higher risk of all cause mortality in women (ratio of relative risks for women compared with men 1.12, 95% confidence interval 1.07 to 1.17) and a significantly stronger risk of stroke (1.99, 1.46 to 2.71), cardiovascular mortality (1.93, 1.44 to 2.60), cardiac events (1.55, 1.15 to 2.08), and heart failure (1.16, 1.07 to 1.27). Results were broadly consistent in sensitivity analyses.
Conclusion: Atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men, though further research would be needed to determine any causality. |
| first_indexed | 2024-09-23T15:38:14Z |
| format | Article |
| id | mit-1721.1/107757 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:38:14Z |
| publishDate | 2017 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1077572022-09-29T15:10:48Z Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies Emdin, Connor A Wong, Christopher X Altman, Douglas G Peters, Sanne AE Woodward, Mark Odutayo, Ayodele A Hsiao, Allan Massachusetts Institute of Technology. Department of Economics Hsiao, Allan Objective: To determine whether atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men. Design: Meta-analysis of cohort studies. Data: sources Studies published between January 1966 and March 2015, identified through a systematic search of Medline and Embase and review of references. Eligibility for selecting studies: Cohort studies with a minimum of 50 participants with and 50 without atrial fibrillation that reported sex specific associations between atrial fibrillation and all cause mortality, cardiovascular mortality, stroke, cardiac events (cardiac death and non-fatal myocardial infarction), and heart failure. Data extraction: Two independent reviewers extracted study characteristics and maximally adjusted sex specific relative risks. Inverse variance weighted random effects meta-analysis was used to pool sex specific relative risks and their ratio. Results: 30 studies with 4 371 714 participants were identified. Atrial fibrillation was associated with a higher risk of all cause mortality in women (ratio of relative risks for women compared with men 1.12, 95% confidence interval 1.07 to 1.17) and a significantly stronger risk of stroke (1.99, 1.46 to 2.71), cardiovascular mortality (1.93, 1.44 to 2.60), cardiac events (1.55, 1.15 to 2.08), and heart failure (1.16, 1.07 to 1.27). Results were broadly consistent in sensitivity analyses. Conclusion: Atrial fibrillation is a stronger risk factor for cardiovascular disease and death in women compared with men, though further research would be needed to determine any causality. Rhodes Scholarship 2017-03-28T17:34:56Z 2017-03-28T17:34:56Z 2016-01 Article http://purl.org/eprint/type/JournalArticle 1756-1833 http://hdl.handle.net/1721.1/107757 Emdin, Connor A et al. “Atrial Fibrillation as Risk Factor for Cardiovascular Disease and Death in Women Compared with Men: Systematic Review and Meta-Analysis of Cohort Studies.” BMJ (2016): h7013. © 2016 BMJ Publishing Group Ltd https://orcid.org/0000-0002-6609-8712 en_US http://dx.doi.org/10.1136/bmj.h7013 BMJ Creative Commons Attribution-NonCommercial 3.0 Unported https://creativecommons.org/licenses/by-nc/3.0/ application/pdf BMJ Publishing Group BMJ Publishing Group |
| spellingShingle | Emdin, Connor A Wong, Christopher X Altman, Douglas G Peters, Sanne AE Woodward, Mark Odutayo, Ayodele A Hsiao, Allan Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies |
| title | Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies |
| title_full | Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies |
| title_fullStr | Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies |
| title_full_unstemmed | Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies |
| title_short | Atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men: systematic review and meta-analysis of cohort studies |
| title_sort | atrial fibrillation as risk factor for cardiovascular disease and death in women compared with men systematic review and meta analysis of cohort studies |
| url | http://hdl.handle.net/1721.1/107757 https://orcid.org/0000-0002-6609-8712 |
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