Controlled Inhibition of the Mesenchymal Stromal Cell Pro-inflammatory Secretome via Microparticle Engineering
Mesenchymal stromal cells (MSCs) are promising therapeutic candidates given their potent immunomodulatory and anti-inflammatory secretome. However, controlling the MSC secretome post-transplantation is considered a major challenge that hinders their clinical efficacy. To address this, we used a micr...
Main Authors: | Ranganath, Sudhir H., Tong, Zhixiang, Levy, Oren, Martyn, Keir, Karp, Jeffrey M., Inamdar, Maneesha S. |
---|---|
Other Authors: | Koch Institute for Integrative Cancer Research at MIT |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2017
|
Online Access: | http://hdl.handle.net/1721.1/108002 |
Similar Items
-
Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease
by: Ranganath, Sudhir H., et al.
Published: (2014) -
Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome
by: Tam, Kimberley, et al.
Published: (2018) -
Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation
by: Yang, Zijiang, et al.
Published: (2017) -
Small interfering RNA silencing of interleukin-6 in mesenchymal stromal cells inhibits multiple myeloma cell growth
by: Teoh, Hoon Koon, et al.
Published: (2016) -
Material Viscoelastic Properties Modulate the Mesenchymal Stem Cell Secretome for Applications in Hematopoietic Recovery
by: Liu, Frances Deen, et al.
Published: (2022)