Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity

Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity

An effective preventive vaccine is highly sought after in order to stem the current HIV-1 pandemic. Both conservation of contiguous gp41 membrane-proximal external region (MPER) amino acid sequences across HIV-1 clades and the ability of anti-MPER broadly neutralizing antibodies (BNAbs) to block vir...

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Bibliographic Details
Main Authors: Donius, Luke R., Cheng, Yuxing, Choi, Jaewon, Sun, Zhen-Yu J., Marquez, Susanna, Uduman, Mohammed, Kleinstein, Steven H., Reinherz, Ellis L., Kim, Mikyung, Hanson, Melissa Catherine, Zhang, Michael H, Irvine, Darrell J, Love, John C, Gierahn, Todd Michael
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Society for Microbiology 2017
Online Access:http://hdl.handle.net/1721.1/108061
https://orcid.org/0000-0003-0921-3144

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