Chromatin regulation at the frontier of synthetic biology
As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chrom...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2017
|
| Online Access: | http://hdl.handle.net/1721.1/108062 https://orcid.org/0000-0001-8958-1232 https://orcid.org/0000-0002-5560-8246 |
| _version_ | 1811084718930657280 |
|---|---|
| author | Joung, J. Keith Khalil, Ahmad S. Keung, Albert Jun Qi Collins, James J. |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Joung, J. Keith Khalil, Ahmad S. Keung, Albert Jun Qi Collins, James J. |
| author_sort | Joung, J. Keith |
| collection | MIT |
| description | As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chromatin, which brings distinct challenges, as well as opportunities, over applications in bacteria. Recent synthetic approaches, including 'epigenome editing', have allowed the direct and functional dissection of many aspects of physiological chromatin regulation. These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication. |
| first_indexed | 2024-09-23T12:56:32Z |
| format | Article |
| id | mit-1721.1/108062 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:56:32Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1080622022-09-28T11:02:21Z Chromatin regulation at the frontier of synthetic biology Joung, J. Keith Khalil, Ahmad S. Keung, Albert Jun Qi Collins, James J. Institute for Medical Engineering and Science Massachusetts Institute of Technology. Department of Biological Engineering Keung, Albert Jun Qi Collins, James J. As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chromatin, which brings distinct challenges, as well as opportunities, over applications in bacteria. Recent synthetic approaches, including 'epigenome editing', have allowed the direct and functional dissection of many aspects of physiological chromatin regulation. These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication. National Institute of General Medical Sciences (U.S.) (Ruth L. Kirschstein Postdoctoral Fellowship ) United States. Defense Advanced Research Projects Agency National Institutes of Health (U.S.) (R24 Grant) Wyss Institute for Biologically Inspired Engineering Howard Hughes Medical Institute 2017-04-12T14:08:10Z 2017-04-12T14:08:10Z 2015-02 Article http://purl.org/eprint/type/JournalArticle 1471-0056 1471-0064 http://hdl.handle.net/1721.1/108062 Keung, Albert J. et al. “Chromatin Regulation at the Frontier of Synthetic Biology.” Nature Reviews Genetics 16.3 (2015): 159–171. https://orcid.org/0000-0001-8958-1232 https://orcid.org/0000-0002-5560-8246 en_US http://dx.doi.org/10.1038/nrg3900 Nature Reviews Genetics Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Joung, J. Keith Khalil, Ahmad S. Keung, Albert Jun Qi Collins, James J. Chromatin regulation at the frontier of synthetic biology |
| title | Chromatin regulation at the frontier of synthetic biology |
| title_full | Chromatin regulation at the frontier of synthetic biology |
| title_fullStr | Chromatin regulation at the frontier of synthetic biology |
| title_full_unstemmed | Chromatin regulation at the frontier of synthetic biology |
| title_short | Chromatin regulation at the frontier of synthetic biology |
| title_sort | chromatin regulation at the frontier of synthetic biology |
| url | http://hdl.handle.net/1721.1/108062 https://orcid.org/0000-0001-8958-1232 https://orcid.org/0000-0002-5560-8246 |
| work_keys_str_mv | AT joungjkeith chromatinregulationatthefrontierofsyntheticbiology AT khalilahmads chromatinregulationatthefrontierofsyntheticbiology AT keungalbertjunqi chromatinregulationatthefrontierofsyntheticbiology AT collinsjamesj chromatinregulationatthefrontierofsyntheticbiology |