Memory Engram Cells Have Come of Age
The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20th century when two guiding theories were presented: the “engram theory” of Richard Semon and Donald Hebb’s “synaptic plasticity...
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| Format: | Article |
| Language: | en_US |
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Elsevier/Cell Press
2017
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| Online Access: | http://hdl.handle.net/1721.1/108066 https://orcid.org/0000-0003-2839-8228 https://orcid.org/0000-0002-6697-8330 |
| _version_ | 1826197258726539264 |
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| author | Tonegawa, Susumu Liu, Xu Ramirez Moreno, Steve Redondo, Roger L. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Tonegawa, Susumu Liu, Xu Ramirez Moreno, Steve Redondo, Roger L. |
| author_sort | Tonegawa, Susumu |
| collection | MIT |
| description | The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20th century when two guiding theories were presented: the “engram theory” of Richard Semon and Donald Hebb’s “synaptic plasticity theory.” While a large number of studies have been conducted since, each supporting some aspect of each of these theories, until recently integrative evidence for the existence of engram cells and circuits as defined by the theories was lacking. In the past few years, the combination of transgenics, optogenetics, and other technologies has allowed neuroscientists to begin identifying memory engram cells by detecting specific populations of cells activated during specific learning epochs and by engineering them not only to evoke recall of the original memory, but also to alter the content of the memory. |
| first_indexed | 2024-09-23T10:45:15Z |
| format | Article |
| id | mit-1721.1/108066 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:45:15Z |
| publishDate | 2017 |
| publisher | Elsevier/Cell Press |
| record_format | dspace |
| spelling | mit-1721.1/1080662022-09-27T14:44:41Z Memory Engram Cells Have Come of Age Tonegawa, Susumu Liu, Xu Ramirez Moreno, Steve Redondo, Roger L. Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory tonegawa, susumu Tonegawa, Susumu Liu, Xu Ramirez Moreno, Steve Redondo Pena, Roger L The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20th century when two guiding theories were presented: the “engram theory” of Richard Semon and Donald Hebb’s “synaptic plasticity theory.” While a large number of studies have been conducted since, each supporting some aspect of each of these theories, until recently integrative evidence for the existence of engram cells and circuits as defined by the theories was lacking. In the past few years, the combination of transgenics, optogenetics, and other technologies has allowed neuroscientists to begin identifying memory engram cells by detecting specific populations of cells activated during specific learning epochs and by engineering them not only to evoke recall of the original memory, but also to alter the content of the memory. RIKEN Brain Science Institute Howard Hughes Medical Institute JPB Foundation 2017-04-12T15:16:40Z 2017-04-12T15:16:40Z 2015-09 Article http://purl.org/eprint/type/JournalArticle 0896-6273 1097-4199 http://hdl.handle.net/1721.1/108066 Tonegawa, Susumu et al. “Memory Engram Cells Have Come of Age.” Neuron 87.5 (2015): 918–931. https://orcid.org/0000-0003-2839-8228 https://orcid.org/0000-0002-6697-8330 en_US http://dx.doi.org/10.1016/j.neuron.2015.08.002 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier/Cell Press Prof. Tonegawa via Courtney Crummett |
| spellingShingle | Tonegawa, Susumu Liu, Xu Ramirez Moreno, Steve Redondo, Roger L. Memory Engram Cells Have Come of Age |
| title | Memory Engram Cells Have Come of Age |
| title_full | Memory Engram Cells Have Come of Age |
| title_fullStr | Memory Engram Cells Have Come of Age |
| title_full_unstemmed | Memory Engram Cells Have Come of Age |
| title_short | Memory Engram Cells Have Come of Age |
| title_sort | memory engram cells have come of age |
| url | http://hdl.handle.net/1721.1/108066 https://orcid.org/0000-0003-2839-8228 https://orcid.org/0000-0002-6697-8330 |
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