Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates
The threat of chemical warfare agents (CWAs) necessitates the development of functional materials that not only quickly detect the presence of CWAs but also actively protect against their toxicity. We have synthesized responsive units that exhibit colorimetric responses upon exposure to CWAs and inc...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Chemical Society (ACS)
2017
|
| Online Access: | http://hdl.handle.net/1721.1/108069 |
| _version_ | 1811088092286681088 |
|---|---|
| author | Belger, Christian Weis, Jonathan Garrett Swager, Timothy M Ahmed, Eilaf |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Belger, Christian Weis, Jonathan Garrett Swager, Timothy M Ahmed, Eilaf |
| author_sort | Belger, Christian |
| collection | MIT |
| description | The threat of chemical warfare agents (CWAs) necessitates the development of functional materials that not only quickly detect the presence of CWAs but also actively protect against their toxicity. We have synthesized responsive units that exhibit colorimetric responses upon exposure to CWAs and incorporated them into a versatile detection platform based on copolymers prepared by ring-opening metathesis polymerization (ROMP). The theoretical detection limits for CWA simulants in solution for these polymers are as low as 1 ppm. By incorporating hydrogel-promoting units as pendant chains, we are able to obtain polymers that instantly respond to CWA vapors and are easy to regenerate to the deactivated state by simple treatment with ammonium hydroxide vapor. We further demonstrate a collapse of the polymer gels in response to trifluoroacetic acid (TFA), a strong acid that produces a more fully ionized state as a result of its more caustic nature. |
| first_indexed | 2024-09-23T13:56:08Z |
| format | Article |
| id | mit-1721.1/108069 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:56:08Z |
| publishDate | 2017 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1080692022-09-28T17:13:07Z Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates Belger, Christian Weis, Jonathan Garrett Swager, Timothy M Ahmed, Eilaf Massachusetts Institute of Technology. Department of Chemistry Swager, Timothy M. Belger, Christian Weis, Jonathan Garrett Swager, Timothy M Ahmed, Eilaf The threat of chemical warfare agents (CWAs) necessitates the development of functional materials that not only quickly detect the presence of CWAs but also actively protect against their toxicity. We have synthesized responsive units that exhibit colorimetric responses upon exposure to CWAs and incorporated them into a versatile detection platform based on copolymers prepared by ring-opening metathesis polymerization (ROMP). The theoretical detection limits for CWA simulants in solution for these polymers are as low as 1 ppm. By incorporating hydrogel-promoting units as pendant chains, we are able to obtain polymers that instantly respond to CWA vapors and are easy to regenerate to the deactivated state by simple treatment with ammonium hydroxide vapor. We further demonstrate a collapse of the polymer gels in response to trifluoroacetic acid (TFA), a strong acid that produces a more fully ionized state as a result of its more caustic nature. United States. Defense Threat Reduction Agency. Chemical and Biological Technologies Department (Grant BA12PHM123) 2017-04-12T15:50:08Z 2017-04-12T15:50:08Z 2015-10 2015-06 Article http://purl.org/eprint/type/JournalArticle 0024-9297 1520-5835 http://hdl.handle.net/1721.1/108069 Belger, Christian et al. “Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates.” Macromolecules 48.21 (2015): 7990–7994. en_US http://dx.doi.org/10.1021/acs.macromol.5b01406 Macromolecules Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) Prof. Swager via Erja Kajosalo |
| spellingShingle | Belger, Christian Weis, Jonathan Garrett Swager, Timothy M Ahmed, Eilaf Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates |
| title | Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates |
| title_full | Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates |
| title_fullStr | Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates |
| title_full_unstemmed | Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates |
| title_short | Colorimetric Stimuli-Responsive Hydrogel Polymers for the Detection of Nerve Agent Surrogates |
| title_sort | colorimetric stimuli responsive hydrogel polymers for the detection of nerve agent surrogates |
| url | http://hdl.handle.net/1721.1/108069 |
| work_keys_str_mv | AT belgerchristian colorimetricstimuliresponsivehydrogelpolymersforthedetectionofnerveagentsurrogates AT weisjonathangarrett colorimetricstimuliresponsivehydrogelpolymersforthedetectionofnerveagentsurrogates AT swagertimothym colorimetricstimuliresponsivehydrogelpolymersforthedetectionofnerveagentsurrogates AT ahmedeilaf colorimetricstimuliresponsivehydrogelpolymersforthedetectionofnerveagentsurrogates |