Contrasting responses within a single neuron class enable sex-specific attraction in
Animals find mates and food, and avoid predators, by navigating to regions within a favorable range of available sensory cues. How are these ranges set and recognized? Here we show that male Caenorhabditis elegans exhibit strong concentration preferences for sex-specific small molecule cues secreted...
| প্রধান লেখক: | , , , , , , , , |
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| অন্যান্য লেখক: | |
| বিন্যাস: | প্রবন্ধ |
| ভাষা: | en_US |
| প্রকাশিত: |
National Academy of Sciences
2017
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| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/1721.1/108072 https://orcid.org/0000-0001-8426-6188 |
| _version_ | 1826206903626104832 |
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| author | Narayan, Anusha Venkatachalam, Vivek Durak, Omer Reilly, Douglas K. Bose, Neelanjan Schroeder, Frank C. Samuel, Aravinthan D. T. Srinivasan, Jagan Sternberg, Paul W. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Narayan, Anusha Venkatachalam, Vivek Durak, Omer Reilly, Douglas K. Bose, Neelanjan Schroeder, Frank C. Samuel, Aravinthan D. T. Srinivasan, Jagan Sternberg, Paul W. |
| author_sort | Narayan, Anusha |
| collection | MIT |
| description | Animals find mates and food, and avoid predators, by navigating to regions within a favorable range of available sensory cues. How are these ranges set and recognized? Here we show that male Caenorhabditis elegans exhibit strong concentration preferences for sex-specific small molecule cues secreted by hermaphrodites, and that these preferences emerge from the collective dynamics of a single male-specific class of neurons, the cephalic sensory neurons (CEMs). Within a single worm, CEM responses are dissimilar, not determined by anatomical classification and can be excitatory or inhibitory. Response kinetics vary by concentration, suggesting a mechanism for establishing preferences. CEM responses are enhanced in the absence of synaptic transmission, and worms with only one intact CEM show nonpreferential attraction to all concentrations of ascaroside for which CEM is the primary sensor, suggesting that synaptic modulation of CEM responses is necessary for establishing preferences. A heterogeneous concentration-dependent sensory representation thus appears to allow a single neural class to set behavioral preferences and recognize ranges of sensory cues. |
| first_indexed | 2024-09-23T13:40:26Z |
| format | Article |
| id | mit-1721.1/108072 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:40:26Z |
| publishDate | 2017 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1080722022-10-01T16:25:22Z Contrasting responses within a single neuron class enable sex-specific attraction in Narayan, Anusha Venkatachalam, Vivek Durak, Omer Reilly, Douglas K. Bose, Neelanjan Schroeder, Frank C. Samuel, Aravinthan D. T. Srinivasan, Jagan Sternberg, Paul W. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Narayan, Anusha Durak, Omer Animals find mates and food, and avoid predators, by navigating to regions within a favorable range of available sensory cues. How are these ranges set and recognized? Here we show that male Caenorhabditis elegans exhibit strong concentration preferences for sex-specific small molecule cues secreted by hermaphrodites, and that these preferences emerge from the collective dynamics of a single male-specific class of neurons, the cephalic sensory neurons (CEMs). Within a single worm, CEM responses are dissimilar, not determined by anatomical classification and can be excitatory or inhibitory. Response kinetics vary by concentration, suggesting a mechanism for establishing preferences. CEM responses are enhanced in the absence of synaptic transmission, and worms with only one intact CEM show nonpreferential attraction to all concentrations of ascaroside for which CEM is the primary sensor, suggesting that synaptic modulation of CEM responses is necessary for establishing preferences. A heterogeneous concentration-dependent sensory representation thus appears to allow a single neural class to set behavioral preferences and recognize ranges of sensory cues. 2017-04-12T16:17:58Z 2017-04-12T16:17:58Z 2016-02 2015-07 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/108072 Narayan, Anusha; Venkatachalam, Vivek; Durak, Omer; Reilly, Douglas K.; Bose, Neelanjan; Schroeder, Frank C.; Samuel, Aravinthan D. T.; Srinivasan, Jagan and Sternberg, Paul W. “ Contrasting Responses Within a Single Neuron Class Enable Sex-Specific Attraction in Caenorhabditis Elegans .” Proceedings of the National Academy of Sciences USA 113, no. 10 (February 22, 2016): E1392–E1401.© 2016 National Academy of Sciences. https://orcid.org/0000-0001-8426-6188 en_US http://dx.doi.org/10.1073/pnas.1600786113 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences PNAS |
| spellingShingle | Narayan, Anusha Venkatachalam, Vivek Durak, Omer Reilly, Douglas K. Bose, Neelanjan Schroeder, Frank C. Samuel, Aravinthan D. T. Srinivasan, Jagan Sternberg, Paul W. Contrasting responses within a single neuron class enable sex-specific attraction in |
| title | Contrasting responses within a single neuron class enable sex-specific attraction in |
| title_full | Contrasting responses within a single neuron class enable sex-specific attraction in |
| title_fullStr | Contrasting responses within a single neuron class enable sex-specific attraction in |
| title_full_unstemmed | Contrasting responses within a single neuron class enable sex-specific attraction in |
| title_short | Contrasting responses within a single neuron class enable sex-specific attraction in |
| title_sort | contrasting responses within a single neuron class enable sex specific attraction in |
| url | http://hdl.handle.net/1721.1/108072 https://orcid.org/0000-0001-8426-6188 |
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