Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation

Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation

Pre-treatment or priming of mesenchymal stem cells (MSC) prior to transplantation can significantly augment the immunosuppressive effect of MSC-based therapies. In this study, we screened a library of 1402 FDA-approved bioactive compounds to prime MSC. We identified tetrandrine as a potential hit th...

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Bibliographic Details
Main Authors: Yang, Zijiang, Concannon, John, Seyb, Kathleen, Mortensen, Luke J., Ranganath, Sudhir, Gu, Fangqi, Levy, Oren, Martyn, Keir, Zhao, Weian, Glicksman, Marcie A., Ng, Kelvin Songyu, Tong, Zhixiang, Lin, Charles, Karp, Jeffrey Michael
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/108076
https://orcid.org/0000-0003-1937-9594

Internet

http://hdl.handle.net/1721.1/108076
https://orcid.org/0000-0003-1937-9594

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