RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice

RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice

The mechanistic target of rapamycin complex 1 (mTORC1) integrates cues from growth factors and nutrients to control metabolism. In contrast to the growth factor input, genetic disruption of nutrient-dependent activation of mTORC1 in mammals remains unexplored. We engineered mice lacking RagA and Rag...

Full description

Bibliographic Details
Main Authors: Kirak, Oktay, Efeyan, Alejo, Schweitzer, Lawrence David, Bilate, Angelina M, Chang, Steven H., Lamming, Dudley, Sabatini, David
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/108081
https://orcid.org/0000-0001-9765-4016
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/108081
https://orcid.org/0000-0001-9765-4016
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-1446-7256

Similar Items