RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice
The mechanistic target of rapamycin complex 1 (mTORC1) integrates cues from growth factors and nutrients to control metabolism. In contrast to the growth factor input, genetic disruption of nutrient-dependent activation of mTORC1 in mammals remains unexplored. We engineered mice lacking RagA and Rag...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/108081 https://orcid.org/0000-0001-9765-4016 https://orcid.org/0000-0002-0079-4467 https://orcid.org/0000-0002-1446-7256 |