Biomaterial Strategies for Immunomodulation
Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for regenerative medicine, and immunotherapies for cancer. However,...
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| Format: | Article |
| Language: | en_US |
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Annual Reviews
2017
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| Online Access: | http://hdl.handle.net/1721.1/108131 https://orcid.org/0000-0002-4244-5978 |
| _version_ | 1826189357317357568 |
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| author | Hotaling, Nathan A. Babensee, Julia E. Tang, Li Irvine, Darrell J |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Hotaling, Nathan A. Babensee, Julia E. Tang, Li Irvine, Darrell J |
| author_sort | Hotaling, Nathan A. |
| collection | MIT |
| description | Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for regenerative medicine, and immunotherapies for cancer. However, the intricate cellular and molecular signals regulating the immune system are major hurdles to predictably manipulating the immune response and developing safe and effective therapies. To meet this challenge, biomaterials are being developed that control how, where, and when immune cells are stimulated in vivo, and that can finely control their differentiation in vitro. We review recent advances in the field of biomaterials for immunomodulation, focusing particularly on designing biomaterials to provide controlled immunostimulation, targeting drugs and vaccines to lymphoid organs, and serving as scaffolds to organize immune cells and emulate lymphoid tissues. These ongoing efforts highlight the many ways in which biomaterials can be brought to bear to engineer the immune system. |
| first_indexed | 2024-09-23T08:13:28Z |
| format | Article |
| id | mit-1721.1/108131 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:13:28Z |
| publishDate | 2017 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | mit-1721.1/1081312022-09-30T08:26:36Z Biomaterial Strategies for Immunomodulation Hotaling, Nathan A. Babensee, Julia E. Tang, Li Irvine, Darrell J Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Koch Institute for Integrative Cancer Research at MIT Tang, Li Irvine, Darrell J Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for regenerative medicine, and immunotherapies for cancer. However, the intricate cellular and molecular signals regulating the immune system are major hurdles to predictably manipulating the immune response and developing safe and effective therapies. To meet this challenge, biomaterials are being developed that control how, where, and when immune cells are stimulated in vivo, and that can finely control their differentiation in vitro. We review recent advances in the field of biomaterials for immunomodulation, focusing particularly on designing biomaterials to provide controlled immunostimulation, targeting drugs and vaccines to lymphoid organs, and serving as scaffolds to organize immune cells and emulate lymphoid tissues. These ongoing efforts highlight the many ways in which biomaterials can be brought to bear to engineer the immune system. Bill & Melinda Gates Foundation United States. Army Research Office. Institute for Soldier Nanotechnologies (Contract W911NF-13-D-0001) Ragon Institute of MGH, MIT and Harvard Cancer Research Institute (New York, N.Y.) (Irvington Postdoctoral Fellowship) National Institutes of Health (U.S.) (Awards AI104715, CA172164, CA174795, and AI095109) 2017-04-13T18:35:10Z 2017-04-13T18:35:10Z 2015-12 2015-09 Article http://purl.org/eprint/type/JournalArticle 1523-9829 1545-4274 http://hdl.handle.net/1721.1/108131 Hotaling, Nathan A., Li Tang, Darrell J. Irvine, and Julia E. Babensee. “Biomaterial Strategies for Immunomodulation.” Annual Review of Biomedical Engineering 17, no. 1 (December 7, 2015): 317–349. https://orcid.org/0000-0002-4244-5978 en_US http://dx.doi.org/10.1146/annurev-bioeng-071813-104814 Annual Review of Biomedical Engineering Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Annual Reviews PMC |
| spellingShingle | Hotaling, Nathan A. Babensee, Julia E. Tang, Li Irvine, Darrell J Biomaterial Strategies for Immunomodulation |
| title | Biomaterial Strategies for Immunomodulation |
| title_full | Biomaterial Strategies for Immunomodulation |
| title_fullStr | Biomaterial Strategies for Immunomodulation |
| title_full_unstemmed | Biomaterial Strategies for Immunomodulation |
| title_short | Biomaterial Strategies for Immunomodulation |
| title_sort | biomaterial strategies for immunomodulation |
| url | http://hdl.handle.net/1721.1/108131 https://orcid.org/0000-0002-4244-5978 |
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