Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications
Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pat...
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/108144 |
| _version_ | 1826211393852932096 |
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| author | Liu, Haipeng Irvine, Darrell J |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Liu, Haipeng Irvine, Darrell J |
| author_sort | Liu, Haipeng |
| collection | MIT |
| description | Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure–function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies. |
| first_indexed | 2024-09-23T15:05:12Z |
| format | Article |
| id | mit-1721.1/108144 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:05:12Z |
| publishDate | 2017 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1081442022-09-29T12:38:12Z Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications Liu, Haipeng Irvine, Darrell J Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Ragon Institute of MGH, MIT and Harvard Koch Institute for Integrative Cancer Research at MIT Irvine, Darrell J Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure–function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies. United States. National Institutes of Health (AI095109) United States. National Institutes of Health (AI091693) United States. National Institutes of Health (AI104715) Ragon Institute of MGH, MIT and Harvard Dana-Farber Cancer Institute. Bridge Project 2017-04-13T19:52:22Z 2017-04-13T19:52:22Z 2015-05 2015-05 Article http://purl.org/eprint/type/JournalArticle 1043-1802 1520-4812 http://hdl.handle.net/1721.1/108144 Liu, Haipeng, and Darrell J. Irvine. “Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications.” Bioconjugate Chemistry 26, no. 5 (May 20, 2015): 791–801. © 2015 American Chemical Society en_US http://dx.doi.org/10.1021/acs.bioconjchem.5b00103 Bioconjugate Chemistry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Liu, Haipeng Irvine, Darrell J Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications |
| title | Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications |
| title_full | Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications |
| title_fullStr | Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications |
| title_full_unstemmed | Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications |
| title_short | Guiding Principles in the Design of Molecular Bioconjugates for Vaccine Applications |
| title_sort | guiding principles in the design of molecular bioconjugates for vaccine applications |
| url | http://hdl.handle.net/1721.1/108144 |
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