Ultrasound-mediated gastrointestinal drug delivery
available in PMC 2016 April 08
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/108145 https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-6410-3784 https://orcid.org/0000-0002-4260-2785 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 |
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| author | Brugge, W. R. Lauwers, Gregory Yves Schoellhammer, Carl Magnus Zervas, Michael J. Traverso, Carlo Giovanni Anderson, Daniel Griffith Langer, Robert S Maa, Ruby C. Schroeder, Avraham Dror Barman, Ross DiCiccio, Angela M Swiston, Albert J., Jr. Blankschtein, Daniel |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Brugge, W. R. Lauwers, Gregory Yves Schoellhammer, Carl Magnus Zervas, Michael J. Traverso, Carlo Giovanni Anderson, Daniel Griffith Langer, Robert S Maa, Ruby C. Schroeder, Avraham Dror Barman, Ross DiCiccio, Angela M Swiston, Albert J., Jr. Blankschtein, Daniel |
| author_sort | Brugge, W. R. |
| collection | MIT |
| description | available in PMC 2016 April 08 |
| first_indexed | 2024-09-23T08:45:28Z |
| format | Article |
| id | mit-1721.1/108145 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:45:28Z |
| publishDate | 2017 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1081452022-09-30T11:04:22Z Ultrasound-mediated gastrointestinal drug delivery Brugge, W. R. Lauwers, Gregory Yves Schoellhammer, Carl Magnus Zervas, Michael J. Traverso, Carlo Giovanni Anderson, Daniel Griffith Langer, Robert S Maa, Ruby C. Schroeder, Avraham Dror Barman, Ross DiCiccio, Angela M Swiston, Albert J., Jr. Blankschtein, Daniel Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Koch Institute for Integrative Cancer Research at MIT Schoellhammer, Carl Magnus Swiston Jr, Albert J. Zervas, Michael J. Traverso, Carlo Giovanni Anderson, Daniel Griffith Blankschtein, Edmundo D Langer, Robert S Maa, Ruby C. Schroeder, Avraham Dror Barman, Ross DiCiccio, Angela M available in PMC 2016 April 08 There is a significant clinical need for rapid and efficient delivery of drugs directly to the site of diseased tissues for the treatment of gastrointestinal (GI) pathologies, in particular, Crohn’s and ulcerative colitis. However, complex therapeutic molecules cannot easily be delivered through the GI tract because of physiologic and structural barriers. We report the use of ultrasound as a modality for enhanced drug delivery to the GI tract, with an emphasis on rectal delivery. Ultrasound increased the absorption of model therapeutics inulin, hydrocortisone, and mesalamine two- to tenfold in ex vivo tissue, depending on location in the GI tract. In pigs, ultrasound induced transient cavitation with negligible heating, leading to an order of magnitude enhancement in the delivery of mesalamine, as well as successful systemic delivery of a macromolecule, insulin, with the expected hypoglycemic response. In a rodent model of chemically induced acute colitis, the addition of ultrasound to a daily mesalamine enema (compared to enema alone) resulted in superior clinical and histological scores of disease activity. In both animal models, ultrasound treatment was well tolerated and resulted in minimal tissue disruption, and in mice, there was no significant effect on histology, fecal score, or tissue inflammatory cytokine levels. The use of ultrasound to enhance GI drug delivery is safe in animals and could augment the efficacy of GI therapies and broaden the scope of agents that could be delivered locally and systemically through the GI tract for chronic conditions such as inflammatory bowel disease. United States. National Institutes of Health (EB-00351) United States. National Institutes of Health (EB-000244) United States. National Institutes of Health (CA014051) United States. National Institutes of Health (T32-DK007191-38-S1) 2017-04-13T20:03:20Z 2017-04-13T20:03:20Z 2015-10 Article http://purl.org/eprint/type/JournalArticle 1946-6234 1946-6242 http://hdl.handle.net/1721.1/108145 Schoellhammer, C. M., A. Schroeder, R. Maa, G. Y. Lauwers, A. Swiston, M. Zervas, R. Barman, et al. “Ultrasound-Mediated Gastrointestinal Drug Delivery.” Science Translational Medicine 7, no. 310 (October 21, 2015): 310ra168–310ra168. https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-6410-3784 https://orcid.org/0000-0002-4260-2785 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1126/scitranslmed.aaa5937 Science Translational Medicine Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Brugge, W. R. Lauwers, Gregory Yves Schoellhammer, Carl Magnus Zervas, Michael J. Traverso, Carlo Giovanni Anderson, Daniel Griffith Langer, Robert S Maa, Ruby C. Schroeder, Avraham Dror Barman, Ross DiCiccio, Angela M Swiston, Albert J., Jr. Blankschtein, Daniel Ultrasound-mediated gastrointestinal drug delivery |
| title | Ultrasound-mediated gastrointestinal drug delivery |
| title_full | Ultrasound-mediated gastrointestinal drug delivery |
| title_fullStr | Ultrasound-mediated gastrointestinal drug delivery |
| title_full_unstemmed | Ultrasound-mediated gastrointestinal drug delivery |
| title_short | Ultrasound-mediated gastrointestinal drug delivery |
| title_sort | ultrasound mediated gastrointestinal drug delivery |
| url | http://hdl.handle.net/1721.1/108145 https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-6410-3784 https://orcid.org/0000-0002-4260-2785 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 |
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