Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks

Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks

A major challenge in developing anticancer therapies is determining the efficacies of drugs and their combinations in physiologically relevant microenvironments. We describe here our application of “constrained fuzzy logic” (CFL) ensemble modeling of the intracellular signaling network for predictin...

书目详细资料
Main Authors:	Morris, Melody Kay, Clarke, David C., Osimiri, Lindsey C., Lauffenburger, Douglas A
其他作者:	Massachusetts Institute of Technology. Department of Biological Engineering
格式:	文件
语言:	en_US
出版:	Nature Publishing Group 2017
在线阅读:	http://hdl.handle.net/1721.1/108162

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