Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion
Frequency domain near-infrared spectroscopy (FD-NIRS) has proven to be a reliable method for quantification of tissue absolute optical properties. We present a full-sampling direct analog-to-digital conversion FD-NIR imager. While we developed this instrument with a focus on high-speed optical breas...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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SPIE
2017
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| Online Access: | http://hdl.handle.net/1721.1/108438 https://orcid.org/0000-0001-9163-3134 |
| _version_ | 1811083518350983168 |
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| author | Fang, Qianqian Boas, David A. Carp, Stefan A. Zimmermann, Bernhard B |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Fang, Qianqian Boas, David A. Carp, Stefan A. Zimmermann, Bernhard B |
| author_sort | Fang, Qianqian |
| collection | MIT |
| description | Frequency domain near-infrared spectroscopy (FD-NIRS) has proven to be a reliable method for quantification of tissue absolute optical properties. We present a full-sampling direct analog-to-digital conversion FD-NIR imager. While we developed this instrument with a focus on high-speed optical breast tomographic imaging, the proposed design is suitable for a wide-range of biophotonic applications where fast, accurate quantification of absolute optical properties is needed. Simultaneous dual wavelength operation at 685 and 830 nm is achieved by concurrent 67.5 and 75 MHz frequency modulation of each laser source, respectively, followed by digitization using a high-speed (180 MS/s) 16-bit A/D converter and hybrid FPGA-assisted demodulation. The instrument supports 25 source locations and features 20 concurrently operating detectors. The noise floor of the instrument was measured at <1.4 pW/√Hz, and a dynamic range of 115+ dB, corresponding to nearly six orders of magnitude, has been demonstrated. Titration experiments consisting of 200 different absorption and scattering values were conducted to demonstrate accurate optical property quantification over the entire range of physiologically expected values. |
| first_indexed | 2024-09-23T12:34:20Z |
| format | Article |
| id | mit-1721.1/108438 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:34:20Z |
| publishDate | 2017 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/1084382022-09-28T08:42:02Z Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion Fang, Qianqian Boas, David A. Carp, Stefan A. Zimmermann, Bernhard B Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Zimmermann, Bernhard B Frequency domain near-infrared spectroscopy (FD-NIRS) has proven to be a reliable method for quantification of tissue absolute optical properties. We present a full-sampling direct analog-to-digital conversion FD-NIR imager. While we developed this instrument with a focus on high-speed optical breast tomographic imaging, the proposed design is suitable for a wide-range of biophotonic applications where fast, accurate quantification of absolute optical properties is needed. Simultaneous dual wavelength operation at 685 and 830 nm is achieved by concurrent 67.5 and 75 MHz frequency modulation of each laser source, respectively, followed by digitization using a high-speed (180 MS/s) 16-bit A/D converter and hybrid FPGA-assisted demodulation. The instrument supports 25 source locations and features 20 concurrently operating detectors. The noise floor of the instrument was measured at <1.4 pW/√Hz, and a dynamic range of 115+ dB, corresponding to nearly six orders of magnitude, has been demonstrated. Titration experiments consisting of 200 different absorption and scattering values were conducted to demonstrate accurate optical property quantification over the entire range of physiologically expected values. United States. National Institutes of Health (R01-CA142575) United States. National Institutes of Health (R01-CA097305) United States. National Institutes of Health (R01-CA187595) United States. National Institutes of Health (R00-EB011889) 2017-04-26T21:45:57Z 2017-04-26T21:45:57Z 2016-01 2015-10 Article http://purl.org/eprint/type/JournalArticle 1083-3668 http://hdl.handle.net/1721.1/108438 Zimmermann, Bernhard B.; Fang, Qianqian; Boas, David A. and Carp, Stefan A. “Frequency Domain Near-Infrared Multiwavelength Imager Design Using High-Speed, Direct Analog-to-Digital Conversion.” Journal of Biomedical Optics 21, no. 1 (January 26, 2016): 016010. © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) https://orcid.org/0000-0001-9163-3134 en_US http://dx.doi.org/10.1117/1.JBO.21.1.016010 Journal of Biomedical Optics Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Fang, Qianqian Boas, David A. Carp, Stefan A. Zimmermann, Bernhard B Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion |
| title | Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion |
| title_full | Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion |
| title_fullStr | Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion |
| title_full_unstemmed | Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion |
| title_short | Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion |
| title_sort | frequency domain near infrared multiwavelength imager design using high speed direct analog to digital conversion |
| url | http://hdl.handle.net/1721.1/108438 https://orcid.org/0000-0001-9163-3134 |
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