Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Cyclin-dependent kinases 12 and 13 (CDK12 and CDK13) play critical roles in the regulation of gene transcription. However, the absence of CDK12 and CDK13 inhibitors has hindered the ability to investigate the consequences of their inhibition in healthy cells and cancer cells. Here we describe the ra...

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Bibliographic Details
Main Authors: Zhang, Tinghu, Kwiatkowski, Nicholas, Olson, Calla M, Dixon-Clarke, Sarah E, Abraham, Brian J, Greifenberg, Ann K, Ficarro, Scott B, Elkins, Jonathan M, Liang, Yanke, Hannett, Nancy M, Manz, Theresa, Hao, Mingfeng, Bartkowiak, Bartlomiej, Greenleaf, Arno L, Marto, Jarrod A, Geyer, Matthias, Bullock, Alex N, Gray, Nathanael S, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/108541
https://orcid.org/0000-0001-8855-8647

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