Radical-mediated ring contraction in the biosynthesis of 7-deazapurines
Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we revi...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/108672 https://orcid.org/0000-0001-5486-2755 |
| _version_ | 1811093302704865280 |
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| author | Bandarian, Vahe Drennan, Catherine L. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bandarian, Vahe Drennan, Catherine L. |
| author_sort | Bandarian, Vahe |
| collection | MIT |
| description | Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase. |
| first_indexed | 2024-09-23T15:43:06Z |
| format | Article |
| id | mit-1721.1/108672 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:43:06Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1086722022-10-02T03:38:12Z Radical-mediated ring contraction in the biosynthesis of 7-deazapurines Bandarian, Vahe Drennan, Catherine L. Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Chemistry Drennan, Catherine L. Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase. 2017-05-04T18:21:35Z 2017-05-04T18:21:35Z 2015-11 Article http://purl.org/eprint/type/JournalArticle 0959-440X http://hdl.handle.net/1721.1/108672 Bandarian, Vahe, and Catherine L Drennan. “Radical-Mediated Ring Contraction in the Biosynthesis of 7-Deazapurines.” Current Opinion in Structural Biology 35 (2015): 116–124. https://orcid.org/0000-0001-5486-2755 en_US http://dx.doi.org/10.1016/j.sbi.2015.11.005 Current Opinion in Structural Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Bandarian, Vahe Drennan, Catherine L. Radical-mediated ring contraction in the biosynthesis of 7-deazapurines |
| title | Radical-mediated ring contraction in the biosynthesis of 7-deazapurines |
| title_full | Radical-mediated ring contraction in the biosynthesis of 7-deazapurines |
| title_fullStr | Radical-mediated ring contraction in the biosynthesis of 7-deazapurines |
| title_full_unstemmed | Radical-mediated ring contraction in the biosynthesis of 7-deazapurines |
| title_short | Radical-mediated ring contraction in the biosynthesis of 7-deazapurines |
| title_sort | radical mediated ring contraction in the biosynthesis of 7 deazapurines |
| url | http://hdl.handle.net/1721.1/108672 https://orcid.org/0000-0001-5486-2755 |
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