The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability

In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are fundamental questions in biology. We found that increased neutral essential amino acid (NEAA) uptake was a critical component of erythropoies...

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Bibliographic Details
Main Authors: Chung, J., Bauer, D. E., Ghamari, A., Nizzi, C. P., Deck, K. M., Kingsley, P. D., Yien, Y. Y., Huston, N. C., Chen, C., Schultz, I. J., Dalton, A. J., Wittig, J. G., Palis, J., Orkin, S. H., Eisenstein, R. S., Cantor, A. B., Paw, B. H., Lodish, Harvey F
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2017
Online Access:http://hdl.handle.net/1721.1/108695
https://orcid.org/0000-0002-7029-7415

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