Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster

Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster

Insulin/insulin-like growth factor signalling (IIS), acting primarily through the PI3-kinase (PI3K)/AKT kinase signalling cassette, plays key evolutionarily conserved regulatory roles in nutrient homeostasis, growth, ageing and longevity. The dysfunction of this pathway has been linked to several ag...

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Detalhes bibliográficos
Principais autores: Davison, Claire, Fan, Shih-Jung, Morris, John F., Goberdhan, Deborah C. I., Wilson, Clive, Mensah, Lawrence
Outros Autores: Massachusetts Institute of Technology. Department of Chemical Engineering
Formato: Artigo
Idioma:en_US
Publicado em: Public Library of Science 2017
Acesso em linha:http://hdl.handle.net/1721.1/108716
https://orcid.org/0000-0003-0939-597X

Internet

http://hdl.handle.net/1721.1/108716
https://orcid.org/0000-0003-0939-597X

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