Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites

The transcription factor T-bet (Tbox protein expressed in T cells) is one of the master regulators of both the innate and adaptive immune responses. It plays a central role in T-cell lineage commitment, where it controls the T[subscript H]1 response, and in gene regulation in plasma B-cells and dend...

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Bibliographic Details
Main Authors: Liu, Ce Feng, Brandt, Gabriel S., Hoang, Quyen Q., Naumova, Natalia, Lazarevic, Vanja, Hwang, Eun Sook, Dekker, Job, Ringe, Dagmar, Petsko, Gregory A., Glimcher, Laurie H
Other Authors: Ragon Institute of MGH, MIT and Harvard
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2017
Online Access:http://hdl.handle.net/1721.1/108727

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