Precision mass measurements in solution reveal properties of single cells and bioparticles
Precise characterization of biological materials ranging from single cells (~1-20 microns) to extracellular vesicles (20-200 nm) is of fundamental interest because of their biological and translational value. Here we discuss the value of precision mass measurements in solution for informing various...
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| Format: | Article |
| Language: | en_US |
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Institute of Electrical and Electronics Engineers
2017
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| Online Access: | http://hdl.handle.net/1721.1/108730 https://orcid.org/0000-0001-5277-6060 https://orcid.org/0000-0001-5223-9433 |
| _version_ | 1811095029333098496 |
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| author | Olcum, Selim A. Cermak, Nathan Manalis, Scott R |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Olcum, Selim A. Cermak, Nathan Manalis, Scott R |
| author_sort | Olcum, Selim A. |
| collection | MIT |
| description | Precise characterization of biological materials ranging from single cells (~1-20 microns) to extracellular vesicles (20-200 nm) is of fundamental interest because of their biological and translational value. Here we discuss the value of precision mass measurements in solution for informing various physical and biological parameters, such as mass accumulation rate, longitudinal cell growth or cell density. We introduce how the limits of the single-particle mass measurements can be pushed down to nano-scale dimensions enabling the resolution of extracellular vesicles and viruses in solution. We believe with future advancements on the precision and throughput of this approach, the capability of analyzing biologically relevant particles in solution will have broad biological and translational impact. |
| first_indexed | 2024-09-23T16:09:23Z |
| format | Article |
| id | mit-1721.1/108730 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:09:23Z |
| publishDate | 2017 |
| publisher | Institute of Electrical and Electronics Engineers |
| record_format | dspace |
| spelling | mit-1721.1/1087302022-10-02T06:44:06Z Precision mass measurements in solution reveal properties of single cells and bioparticles Olcum, Selim A. Cermak, Nathan Manalis, Scott R Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Program in Media Arts and Sciences (Massachusetts Institute of Technology) Koch Institute for Integrative Cancer Research at MIT Manalis, Scott Olcum, Selim A. Cermak, Nathan Manalis, Scott R Precise characterization of biological materials ranging from single cells (~1-20 microns) to extracellular vesicles (20-200 nm) is of fundamental interest because of their biological and translational value. Here we discuss the value of precision mass measurements in solution for informing various physical and biological parameters, such as mass accumulation rate, longitudinal cell growth or cell density. We introduce how the limits of the single-particle mass measurements can be pushed down to nano-scale dimensions enabling the resolution of extracellular vesicles and viruses in solution. We believe with future advancements on the precision and throughput of this approach, the capability of analyzing biologically relevant particles in solution will have broad biological and translational impact. 2017-05-08T13:58:30Z 2017-05-08T13:58:30Z 2015-12 Article http://purl.org/eprint/type/ConferencePaper 978-1-4673-9894-7 http://hdl.handle.net/1721.1/108730 Olcum, Selim, Nathan Cermak, and Scott R. Manalis. “Precision Mass Measurements in Solution Reveal Properties of Single Cells and Bioparticles.” 2015 IEEE International Electron Devices Meeting (IEDM) (December 2015). https://orcid.org/0000-0001-5277-6060 https://orcid.org/0000-0001-5223-9433 en_US http://dx.doi.org/10.1109/IEDM.2015.7409691 2015 IEEE International Electron Devices Meeting (IEDM) Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Institute of Electrical and Electronics Engineers Prof. Manalis via Howard Silver |
| spellingShingle | Olcum, Selim A. Cermak, Nathan Manalis, Scott R Precision mass measurements in solution reveal properties of single cells and bioparticles |
| title | Precision mass measurements in solution reveal properties of single cells and bioparticles |
| title_full | Precision mass measurements in solution reveal properties of single cells and bioparticles |
| title_fullStr | Precision mass measurements in solution reveal properties of single cells and bioparticles |
| title_full_unstemmed | Precision mass measurements in solution reveal properties of single cells and bioparticles |
| title_short | Precision mass measurements in solution reveal properties of single cells and bioparticles |
| title_sort | precision mass measurements in solution reveal properties of single cells and bioparticles |
| url | http://hdl.handle.net/1721.1/108730 https://orcid.org/0000-0001-5277-6060 https://orcid.org/0000-0001-5223-9433 |
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