Acid activation mechanism of the influenza A M2 proton channel

The homotetrameric influenza A M2 channel (AM2) is an acid-activated proton channel responsible for the acidification of the influenza virus interior, an important step in the viral lifecycle. Four histidine residues (His37) in the center of the channel act as a pH sensor and proton selectivity filt...

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Bibliographic Details
Main Authors: Liang, Ruibin, Swanson, Jessica M. J., Madsen, Jesper J., Hong, Mei, DeGrado, William F., Voth, Gregory A.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2017
Online Access:http://hdl.handle.net/1721.1/108731
https://orcid.org/0000-0001-5255-5858