Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery
Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model...
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| Format: | Article |
| Language: | en_US |
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ASME International
2017
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| Online Access: | http://hdl.handle.net/1721.1/108758 https://orcid.org/0000-0002-0109-3515 https://orcid.org/0000-0003-4304-3484 |
| _version_ | 1826215199274696704 |
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| author | Zhu, Xiaoxiang Braatz, Richard D |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Zhu, Xiaoxiang Braatz, Richard D |
| author_sort | Zhu, Xiaoxiang |
| collection | MIT |
| description | Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent drug delivery, distribution, and drug pharmacokinetics in the arterial wall. The integrated model takes into account the PLGA degradation and erosion, anisotropic drug diffusion in the arterial wall, and reversible drug binding. The model simulations first compare the drug delivery from a biodegradable PLGA coating with that from a biodurable coating, including the drug release profiles in the coating, average arterial drug levels, and arterial drug distribution. Using the model for the PLGA stent coating, the simulations further investigate drug internalization, interstitial fluid flow in the arterial wall, and stent embedment for their impact on drug delivery. Simulation results show that these three factors, while imposing little change in the drug release profiles, can greatly change the average drug concentrations in the arterial wall. In particular, each of the factors leads to significant and yet distinguished alterations in the arterial drug distribution that can potentially influence the treatment outcomes. The detailed integrated model provides insights into the design and evaluation of biodegradable PLGA-coated drug-eluting stents for improved intravascular drug delivery. |
| first_indexed | 2024-09-23T16:18:51Z |
| format | Article |
| id | mit-1721.1/108758 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:18:51Z |
| publishDate | 2017 |
| publisher | ASME International |
| record_format | dspace |
| spelling | mit-1721.1/1087582022-09-29T19:32:24Z Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery Zhu, Xiaoxiang Braatz, Richard D Massachusetts Institute of Technology. Department of Chemical Engineering Zhu, Xiaoxiang Braatz, Richard D Increasing interests have been raised toward the potential applications of biodegradable poly(lactic-co-glycolic acid) (PLGA) coatings for drug-eluting stents in order to improve the drug delivery and reduce adverse outcomes in stented arteries in patients. This article presents a mathematical model to describe the integrated processes of drug release in a stent with PLGA coating and subsequent drug delivery, distribution, and drug pharmacokinetics in the arterial wall. The integrated model takes into account the PLGA degradation and erosion, anisotropic drug diffusion in the arterial wall, and reversible drug binding. The model simulations first compare the drug delivery from a biodegradable PLGA coating with that from a biodurable coating, including the drug release profiles in the coating, average arterial drug levels, and arterial drug distribution. Using the model for the PLGA stent coating, the simulations further investigate drug internalization, interstitial fluid flow in the arterial wall, and stent embedment for their impact on drug delivery. Simulation results show that these three factors, while imposing little change in the drug release profiles, can greatly change the average drug concentrations in the arterial wall. In particular, each of the factors leads to significant and yet distinguished alterations in the arterial drug distribution that can potentially influence the treatment outcomes. The detailed integrated model provides insights into the design and evaluation of biodegradable PLGA-coated drug-eluting stents for improved intravascular drug delivery. National Institutes of Health (U.S.) (NIBIB 5RO1EB005181) 2017-05-08T19:49:07Z 2017-05-08T19:49:07Z 2014-09 2014-07 Article http://purl.org/eprint/type/JournalArticle 0148-0731 http://hdl.handle.net/1721.1/108758 Zhu, Xiaoxiang, and Richard D. Braatz. “Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery.” Journal of Biomechanical Engineering 136.11 (2014): 111004. © 2014 by ASME https://orcid.org/0000-0002-0109-3515 https://orcid.org/0000-0003-4304-3484 en_US http://dx.doi.org/10.1115/1.4028135 Journal of Biomechanical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf ASME International American Society of Mechanical Engineers (ASME) |
| spellingShingle | Zhu, Xiaoxiang Braatz, Richard D Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery |
| title | Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery |
| title_full | Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery |
| title_fullStr | Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery |
| title_full_unstemmed | Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery |
| title_short | Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery |
| title_sort | modeling and analysis of drug eluting stents with biodegradable plga coating consequences on intravascular drug delivery |
| url | http://hdl.handle.net/1721.1/108758 https://orcid.org/0000-0002-0109-3515 https://orcid.org/0000-0003-4304-3484 |
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