Metabolic Characterization of the Common Marmoset (Callithrix jacchus)
High-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species. At present, however, there is very little information to help guide experimental design for study of wild populations....
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| Format: | Article |
| Language: | en_US |
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Public Library of Science
2017
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| Online Access: | http://hdl.handle.net/1721.1/108819 |
| _version_ | 1811098351363424256 |
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| author | Go, Young-Mi Liang, Yongliang Uppal, Karan Soltow, Quinlyn A. Promislow, Daniel E. L. Jones, Dean P. Wachtman, Lynn M. |
| author2 | Massachusetts Institute of Technology. Division of Comparative Medicine |
| author_facet | Massachusetts Institute of Technology. Division of Comparative Medicine Go, Young-Mi Liang, Yongliang Uppal, Karan Soltow, Quinlyn A. Promislow, Daniel E. L. Jones, Dean P. Wachtman, Lynn M. |
| author_sort | Go, Young-Mi |
| collection | MIT |
| description | High-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species. At present, however, there is very little information to help guide experimental design for study of wild populations. In a previous non-targeted metabolomics study of common marmosets (Callithrix jacchus), Rhesus macaques, humans, and four non-primate mammalian species, we found that essential amino acids (AA) and other central metabolites had interspecies variation similar to intraspecies variation while non-essential AA, environmental chemicals and catabolic waste products had greater interspecies variation. The present study was designed to test whether 55 plasma metabolites, including both nutritionally essential and non-essential metabolites and catabolic products, differ in concentration in common marmosets and humans. Significant differences were present for more than half of the metabolites analyzed and included AA, vitamins and central lipid metabolites, as well as for catabolic products of AA, nucleotides, energy metabolism and heme. Three environmental chemicals were present at low nanomolar concentrations but did not differ between species. Sex and age differences in marmosets were present for AA and nucleotide metabolism and warrant additional study. Overall, the results suggest that quantitative, targeted metabolomics can provide a useful complement to non-targeted metabolomics for studies of diet and environment interactions in primate evolution. |
| first_indexed | 2024-09-23T17:13:42Z |
| format | Article |
| id | mit-1721.1/108819 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:13:42Z |
| publishDate | 2017 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | mit-1721.1/1088192022-09-30T00:36:29Z Metabolic Characterization of the Common Marmoset (Callithrix jacchus) Go, Young-Mi Liang, Yongliang Uppal, Karan Soltow, Quinlyn A. Promislow, Daniel E. L. Jones, Dean P. Wachtman, Lynn M. Massachusetts Institute of Technology. Division of Comparative Medicine Wachtman, Lynn M. High-resolution metabolomics has created opportunity to integrate nutrition and metabolism into genetic studies to improve understanding of the diverse radiation of primate species. At present, however, there is very little information to help guide experimental design for study of wild populations. In a previous non-targeted metabolomics study of common marmosets (Callithrix jacchus), Rhesus macaques, humans, and four non-primate mammalian species, we found that essential amino acids (AA) and other central metabolites had interspecies variation similar to intraspecies variation while non-essential AA, environmental chemicals and catabolic waste products had greater interspecies variation. The present study was designed to test whether 55 plasma metabolites, including both nutritionally essential and non-essential metabolites and catabolic products, differ in concentration in common marmosets and humans. Significant differences were present for more than half of the metabolites analyzed and included AA, vitamins and central lipid metabolites, as well as for catabolic products of AA, nucleotides, energy metabolism and heme. Three environmental chemicals were present at low nanomolar concentrations but did not differ between species. Sex and age differences in marmosets were present for AA and nucleotide metabolism and warrant additional study. Overall, the results suggest that quantitative, targeted metabolomics can provide a useful complement to non-targeted metabolomics for studies of diet and environment interactions in primate evolution. National Institutes of Health (U.S.) (grant AG038746) 2017-05-11T17:41:56Z 2017-05-11T17:41:56Z 2015-11 2015-09 Article http://purl.org/eprint/type/JournalArticle 1932-6203 http://hdl.handle.net/1721.1/108819 Go, Young-Mi, Yongliang Liang, Karan Uppal, Quinlyn A. Soltow, Daniel E. L. Promislow, Lynn M. Wachtman, and Dean P. Jones. “Metabolic Characterization of the Common Marmoset (Callithrix Jacchus).” Edited by Anand Swaroop. PLoS ONE 10, no. 11 (November 18, 2015): e0142916. en_US http://dx.doi.org/10.1371/journal.pone.0142916 PLoS ONE Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science Public Library of Science |
| spellingShingle | Go, Young-Mi Liang, Yongliang Uppal, Karan Soltow, Quinlyn A. Promislow, Daniel E. L. Jones, Dean P. Wachtman, Lynn M. Metabolic Characterization of the Common Marmoset (Callithrix jacchus) |
| title | Metabolic Characterization of the Common Marmoset (Callithrix jacchus) |
| title_full | Metabolic Characterization of the Common Marmoset (Callithrix jacchus) |
| title_fullStr | Metabolic Characterization of the Common Marmoset (Callithrix jacchus) |
| title_full_unstemmed | Metabolic Characterization of the Common Marmoset (Callithrix jacchus) |
| title_short | Metabolic Characterization of the Common Marmoset (Callithrix jacchus) |
| title_sort | metabolic characterization of the common marmoset callithrix jacchus |
| url | http://hdl.handle.net/1721.1/108819 |
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