Low-level light treatment ameliorates immune thrombocytopenia
Immune thrombocytopenia (ITP) is an immune-mediated acquired bleeding disorder characterized by abnormally low platelet counts. We reported here the ability of low-level light treatment (LLLT) to alleviate ITP in mice. The treatment is based on noninvasive whole body illumination 30 min a day for a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/108825 |
| _version_ | 1811089220460085248 |
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| author | Yang, Jingke Zhang, Qi Li, Peiyu Dong, Tingting Wu, Mei X |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Yang, Jingke Zhang, Qi Li, Peiyu Dong, Tingting Wu, Mei X |
| author_sort | Yang, Jingke |
| collection | MIT |
| description | Immune thrombocytopenia (ITP) is an immune-mediated acquired bleeding disorder characterized by abnormally low platelet counts. We reported here the ability of low-level light treatment (LLLT) to alleviate ITP in mice. The treatment is based on noninvasive whole body illumination 30 min a day for a few consecutive days by near infrared light (830 nm) transmitted by an array of light-emitting diodes (LEDs). LLLT significantly lifted the nadir of platelet counts and restored tail bleeding time when applied to two passive ITP models induced by anti-CD41 antibody. The anti-platelet antibody hindered megakaryocyte differentiation from the progenitors, impaired proplatelet and platelet formation, and induced apoptosis of platelets. These adverse effects of anti-CD41 antibody were all mitigated by LLLT to varying degrees, owing to its ability to enhance mitochondrial biogenesis and activity in megakaryocytes and preserve mitochondrial functions in platelets in the presence of the antibody. The observations argue not only for contribution of mitochondrial stress to the pathology of ITP, but also clinical potentials of LLLT as a safe, simple, and cost-effective modality of ITP. |
| first_indexed | 2024-09-23T14:15:45Z |
| format | Article |
| id | mit-1721.1/108825 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:15:45Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1088252022-09-28T19:36:12Z Low-level light treatment ameliorates immune thrombocytopenia Yang, Jingke Zhang, Qi Li, Peiyu Dong, Tingting Wu, Mei X Harvard University--MIT Division of Health Sciences and Technology Wu, Mei X Immune thrombocytopenia (ITP) is an immune-mediated acquired bleeding disorder characterized by abnormally low platelet counts. We reported here the ability of low-level light treatment (LLLT) to alleviate ITP in mice. The treatment is based on noninvasive whole body illumination 30 min a day for a few consecutive days by near infrared light (830 nm) transmitted by an array of light-emitting diodes (LEDs). LLLT significantly lifted the nadir of platelet counts and restored tail bleeding time when applied to two passive ITP models induced by anti-CD41 antibody. The anti-platelet antibody hindered megakaryocyte differentiation from the progenitors, impaired proplatelet and platelet formation, and induced apoptosis of platelets. These adverse effects of anti-CD41 antibody were all mitigated by LLLT to varying degrees, owing to its ability to enhance mitochondrial biogenesis and activity in megakaryocytes and preserve mitochondrial functions in platelets in the presence of the antibody. The observations argue not only for contribution of mitochondrial stress to the pathology of ITP, but also clinical potentials of LLLT as a safe, simple, and cost-effective modality of ITP. 2017-05-11T18:18:02Z 2017-05-11T18:18:02Z 2016-11 2016-07 Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/108825 Yang, Jingke et al. “Low-Level Light Treatment Ameliorates Immune Thrombocytopenia.” Scientific Reports 6.1 (2016): n. pag. en_US http://dx.doi.org/10.1038/srep38238 Scientific Reports Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature |
| spellingShingle | Yang, Jingke Zhang, Qi Li, Peiyu Dong, Tingting Wu, Mei X Low-level light treatment ameliorates immune thrombocytopenia |
| title | Low-level light treatment ameliorates immune thrombocytopenia |
| title_full | Low-level light treatment ameliorates immune thrombocytopenia |
| title_fullStr | Low-level light treatment ameliorates immune thrombocytopenia |
| title_full_unstemmed | Low-level light treatment ameliorates immune thrombocytopenia |
| title_short | Low-level light treatment ameliorates immune thrombocytopenia |
| title_sort | low level light treatment ameliorates immune thrombocytopenia |
| url | http://hdl.handle.net/1721.1/108825 |
| work_keys_str_mv | AT yangjingke lowlevellighttreatmentamelioratesimmunethrombocytopenia AT zhangqi lowlevellighttreatmentamelioratesimmunethrombocytopenia AT lipeiyu lowlevellighttreatmentamelioratesimmunethrombocytopenia AT dongtingting lowlevellighttreatmentamelioratesimmunethrombocytopenia AT wumeix lowlevellighttreatmentamelioratesimmunethrombocytopenia |