Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1
mTORC1 controls key processes that regulate cell growth, including mRNA translation, ribosome biogenesis, and autophagy. Environmental amino acids activate mTORC1 by promoting its recruitment to the cytosolic surface of the lysosome, where its kinase is activated downstream of growth factor signalin...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/109108 https://orcid.org/0000-0001-9765-4016 https://orcid.org/0000-0002-1446-7256 |