A miniature CSTR cascade for continuous flow of reactions containing solids
Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine chemicals. We present a new miniature continuous stirred-tank reactor (CSTR) cascade to handle solid-forming reactions in flow. Single-phase residence time distribution (RTD) measurements...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry, The
2017
|
| Online Access: | http://hdl.handle.net/1721.1/109210 https://orcid.org/0000-0002-7031-1133 https://orcid.org/0000-0001-7192-580X |
| _version_ | 1826212610938241024 |
|---|---|
| author | Mo, Yiming Jensen, Klavs F |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Mo, Yiming Jensen, Klavs F |
| author_sort | Mo, Yiming |
| collection | MIT |
| description | Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine chemicals. We present a new miniature continuous stirred-tank reactor (CSTR) cascade to handle solid-forming reactions in flow. Single-phase residence time distribution (RTD) measurements of the CSTR cascade reveal nearly ideal CSTR mixing behavior of the individual units. Consistency of experimental and predicted conversions of a Diels–Alder reaction further confirms the CSTR performance. Two solid-forming reactions, (i) glyoxal reacting with cyclohexylamine to form N,N′-dicyclohexylethylenediimine, (ii) sulfonylation of 2-octanol with methanesulfonyl chloride, demonstrate the ability of the reactor cascade to transport solid particles continuously for hours without significant signs of clogging. |
| first_indexed | 2024-09-23T15:28:12Z |
| format | Article |
| id | mit-1721.1/109210 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:28:12Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry, The |
| record_format | dspace |
| spelling | mit-1721.1/1092102022-10-02T02:47:38Z A miniature CSTR cascade for continuous flow of reactions containing solids Mo, Yiming Jensen, Klavs F Massachusetts Institute of Technology. Department of Chemical Engineering Mo, Yiming Jensen, Klavs F Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine chemicals. We present a new miniature continuous stirred-tank reactor (CSTR) cascade to handle solid-forming reactions in flow. Single-phase residence time distribution (RTD) measurements of the CSTR cascade reveal nearly ideal CSTR mixing behavior of the individual units. Consistency of experimental and predicted conversions of a Diels–Alder reaction further confirms the CSTR performance. Two solid-forming reactions, (i) glyoxal reacting with cyclohexylamine to form N,N′-dicyclohexylethylenediimine, (ii) sulfonylation of 2-octanol with methanesulfonyl chloride, demonstrate the ability of the reactor cascade to transport solid particles continuously for hours without significant signs of clogging. 2017-05-19T15:51:24Z 2017-05-19T15:51:24Z 2016-08 2016-07 Article http://purl.org/eprint/type/JournalArticle 2058-9883 http://hdl.handle.net/1721.1/109210 Mo, Yiming and Jensen, Klavs F. “A Miniature CSTR Cascade for Continuous Flow of Reactions Containing Solids.” Reaction Chemistry & Engineering 1, no. 5 (August 2016): 501–507. © 2016 The Royal Society of Chemistry https://orcid.org/0000-0002-7031-1133 https://orcid.org/0000-0001-7192-580X en_US http://dx.doi.org/10.1039/C6RE00132G Reaction Chemistry & Engineering Creative Commons Attribution 3.0 Unported license http://creativecommons.org/licenses/by/3.0/ application/pdf Royal Society of Chemistry, The Royal Society of Chemistry |
| spellingShingle | Mo, Yiming Jensen, Klavs F A miniature CSTR cascade for continuous flow of reactions containing solids |
| title | A miniature CSTR cascade for continuous flow of reactions containing solids |
| title_full | A miniature CSTR cascade for continuous flow of reactions containing solids |
| title_fullStr | A miniature CSTR cascade for continuous flow of reactions containing solids |
| title_full_unstemmed | A miniature CSTR cascade for continuous flow of reactions containing solids |
| title_short | A miniature CSTR cascade for continuous flow of reactions containing solids |
| title_sort | miniature cstr cascade for continuous flow of reactions containing solids |
| url | http://hdl.handle.net/1721.1/109210 https://orcid.org/0000-0002-7031-1133 https://orcid.org/0000-0001-7192-580X |
| work_keys_str_mv | AT moyiming aminiaturecstrcascadeforcontinuousflowofreactionscontainingsolids AT jensenklavsf aminiaturecstrcascadeforcontinuousflowofreactionscontainingsolids AT moyiming miniaturecstrcascadeforcontinuousflowofreactionscontainingsolids AT jensenklavsf miniaturecstrcascadeforcontinuousflowofreactionscontainingsolids |