Does Glyphosate Acting as a Glycine Analogue Contribute To ALS?
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease involving several protein mutations in glycine-rich regions with limited treatment options. 90 - 95% of all cases are non-familial with epidemiological studies showing a significant increased risk in glyphosate-exposed workers...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Ommega Publishers
2017
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| Online Access: | http://hdl.handle.net/1721.1/109267 https://orcid.org/0000-0001-8191-1049 |
| _version_ | 1826196595622805504 |
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| author | Seneff, Stephanie Morley, Wendy A. Hadden, Michael J. Michener, Martin C. |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Seneff, Stephanie Morley, Wendy A. Hadden, Michael J. Michener, Martin C. |
| author_sort | Seneff, Stephanie |
| collection | MIT |
| description | Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease involving several protein mutations in glycine-rich regions with limited treatment options. 90 - 95% of all cases are non-familial with epidemiological studies showing a significant increased risk in glyphosate-exposed workers. In this paper, we propose that glyphosate, the active ingredient in Roundup®, plays a role in ALS, mainly through mistakenly substituting for glycine during protein synthesis, disruption of mineral homeostasis as well as setting up a state of dysbiosis. Mouse models of ALS reveal a pre-symptomatic profile of gut dysbiosis. This dysbiotic state initiate a cascade of events initially impairing metabolism in the gut, and, ultimately, through a series of intermediate stages, leading to motor neuron axonal damage seen in ALS. Lipopolysaccharide, a toxic by-product of dysbiosis which contributes to the pathology, is shown to be statistically higher in ALS patients. In this paper we paint a compelling view of how glyphosate exerts its deleterious effects, including mitochondrial stress and oxidative damage through glycine substitution. Furthermore, its mineral chelation properties disrupt manganese, copper and zinc balance, and it induces glutamate toxicity in the synapse, which results in a die-back phenomenon in axons of motor neurons supplying the damaged skeletal muscles. |
| first_indexed | 2024-09-23T10:30:22Z |
| format | Article |
| id | mit-1721.1/109267 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:30:22Z |
| publishDate | 2017 |
| publisher | Ommega Publishers |
| record_format | dspace |
| spelling | mit-1721.1/1092672022-09-27T09:51:06Z Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? Seneff, Stephanie Morley, Wendy A. Hadden, Michael J. Michener, Martin C. Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Seneff, Stephanie Seneff, Stephanie Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease involving several protein mutations in glycine-rich regions with limited treatment options. 90 - 95% of all cases are non-familial with epidemiological studies showing a significant increased risk in glyphosate-exposed workers. In this paper, we propose that glyphosate, the active ingredient in Roundup®, plays a role in ALS, mainly through mistakenly substituting for glycine during protein synthesis, disruption of mineral homeostasis as well as setting up a state of dysbiosis. Mouse models of ALS reveal a pre-symptomatic profile of gut dysbiosis. This dysbiotic state initiate a cascade of events initially impairing metabolism in the gut, and, ultimately, through a series of intermediate stages, leading to motor neuron axonal damage seen in ALS. Lipopolysaccharide, a toxic by-product of dysbiosis which contributes to the pathology, is shown to be statistically higher in ALS patients. In this paper we paint a compelling view of how glyphosate exerts its deleterious effects, including mitochondrial stress and oxidative damage through glycine substitution. Furthermore, its mineral chelation properties disrupt manganese, copper and zinc balance, and it induces glutamate toxicity in the synapse, which results in a die-back phenomenon in axons of motor neurons supplying the damaged skeletal muscles. 2017-05-22T19:17:47Z 2017-05-22T19:17:47Z 2016-11 2016-10 Article http://purl.org/eprint/type/JournalArticle 2381-0793 http://hdl.handle.net/1721.1/109267 Seneff, Stephanie; Morley, Wendy A.; Hadden, Michael J. and Michener, Martin C. “Does Glyphosate Acting as a Glycine Analogue Contribute To ALS?” Journal of Bioinformatics and Proteomics Review 2, no. 3 (November 2016): 1–21 © 2017 Seneff, S. https://orcid.org/0000-0001-8191-1049 en_US http://dx.doi.org/10.15436/2381-0793.16.1173 Journal of Bioinformatics and Proteomics Review Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Ommega Publishers Seneff |
| spellingShingle | Seneff, Stephanie Morley, Wendy A. Hadden, Michael J. Michener, Martin C. Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? |
| title | Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? |
| title_full | Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? |
| title_fullStr | Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? |
| title_full_unstemmed | Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? |
| title_short | Does Glyphosate Acting as a Glycine Analogue Contribute To ALS? |
| title_sort | does glyphosate acting as a glycine analogue contribute to als |
| url | http://hdl.handle.net/1721.1/109267 https://orcid.org/0000-0001-8191-1049 |
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