Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum
“Fluoro” refers to both fluorescent and fluorinated compounds. Despite the shared prefix, there are very few fluorescent molecules that are soluble in perfluorinated solvents. This paucity is surprising, given that optical microscopy is a ubiquitous technique throughout the physical sciences and the...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/109286 |
| _version_ | 1826205920501170176 |
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| author | Sletten, Ellen M. Swager, Timothy M |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Sletten, Ellen M. Swager, Timothy M |
| author_sort | Sletten, Ellen M. |
| collection | MIT |
| description | “Fluoro” refers to both fluorescent and fluorinated compounds. Despite the shared prefix, there are very few fluorescent molecules that are soluble in perfluorinated solvents. This paucity is surprising, given that optical microscopy is a ubiquitous technique throughout the physical sciences and the orthogonality of fluorous materials is a commonly exploited strategy in synthetic chemistry, materials science, and chemical biology. We have addressed this shortage by synthesizing a panel of “fluorofluorophores,” fluorescent molecules containing high weight percent fluorine with optical properties spanning the visible spectrum. We demonstrate the utility of these fluorofluorophores by preparing fluorescent perfluorocarbon nanoemulsions. |
| first_indexed | 2024-09-23T13:21:09Z |
| format | Article |
| id | mit-1721.1/109286 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:21:09Z |
| publishDate | 2017 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1092862022-10-01T14:44:53Z Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum Sletten, Ellen M. Swager, Timothy M Massachusetts Institute of Technology. Department of Chemistry Sletten, Ellen M. Swager, Timothy M “Fluoro” refers to both fluorescent and fluorinated compounds. Despite the shared prefix, there are very few fluorescent molecules that are soluble in perfluorinated solvents. This paucity is surprising, given that optical microscopy is a ubiquitous technique throughout the physical sciences and the orthogonality of fluorous materials is a commonly exploited strategy in synthetic chemistry, materials science, and chemical biology. We have addressed this shortage by synthesizing a panel of “fluorofluorophores,” fluorescent molecules containing high weight percent fluorine with optical properties spanning the visible spectrum. We demonstrate the utility of these fluorofluorophores by preparing fluorescent perfluorocarbon nanoemulsions. National Science Foundation (U.S.) (ECCS-0939514) 2017-05-23T14:25:08Z 2017-05-23T14:25:08Z 2014-09 2014-07 Article http://purl.org/eprint/type/JournalArticle 0002-7863 1520-5126 http://hdl.handle.net/1721.1/109286 Sletten, Ellen M. and Swager, Timothy M. "Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum." Journal of the American Chemical Society 136, no. 39 (September 2014): 13574-13577 © 2014 American Chemical Society en_US http://dx.doi.org/10.1021/ja507848f Journal of the American Chemical Society Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Sletten, Ellen M. Swager, Timothy M Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum |
| title | Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum |
| title_full | Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum |
| title_fullStr | Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum |
| title_full_unstemmed | Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum |
| title_short | Fluorofluorophores: Fluorescent Fluorous Chemical Tools Spanning the Visible Spectrum |
| title_sort | fluorofluorophores fluorescent fluorous chemical tools spanning the visible spectrum |
| url | http://hdl.handle.net/1721.1/109286 |
| work_keys_str_mv | AT slettenellenm fluorofluorophoresfluorescentfluorouschemicaltoolsspanningthevisiblespectrum AT swagertimothym fluorofluorophoresfluorescentfluorouschemicaltoolsspanningthevisiblespectrum |