Dietary Microbes Modulate Transgenerational Cancer Risk
Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary...
Main Authors: | , , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
American Association for Cancer Research
2017
|
Online Access: | http://hdl.handle.net/1721.1/109330 https://orcid.org/0000-0002-8033-8380 https://orcid.org/0000-0001-8294-9364 |
_version_ | 1811083478780870656 |
---|---|
author | Chatzigiagkos, A. Kearney, Sean M Alm, Eric J Poutahidis, Theofilos Varian, Bernard Urman, Tatiana Lakritz, Jessica Mirabal, Sheyla Kwok, Caitlin Ibrahim, Yassin M Erdman, Susan E |
author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Chatzigiagkos, A. Kearney, Sean M Alm, Eric J Poutahidis, Theofilos Varian, Bernard Urman, Tatiana Lakritz, Jessica Mirabal, Sheyla Kwok, Caitlin Ibrahim, Yassin M Erdman, Susan E |
author_sort | Chatzigiagkos, A. |
collection | MIT |
description | Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer. |
first_indexed | 2024-09-23T12:33:42Z |
format | Article |
id | mit-1721.1/109330 |
institution | Massachusetts Institute of Technology |
language | en_US |
last_indexed | 2024-09-23T12:33:42Z |
publishDate | 2017 |
publisher | American Association for Cancer Research |
record_format | dspace |
spelling | mit-1721.1/1093302022-09-28T08:37:29Z Dietary Microbes Modulate Transgenerational Cancer Risk Chatzigiagkos, A. Kearney, Sean M Alm, Eric J Poutahidis, Theofilos Varian, Bernard Urman, Tatiana Lakritz, Jessica Mirabal, Sheyla Kwok, Caitlin Ibrahim, Yassin M Erdman, Susan E Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Kearney, Sean M Alm, Eric J Poutahidis, Theofilos Varian, Bernard Urman, Tatiana Lakritz, Jessica Mirabal, Sheyla Kwok, Caitlin Ibrahim, Yassin M Erdman, Susan E Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer. National Institutes of Health (U.S.) (RO1CA108854) National Institutes of Health (U.S.) (U01 CA164337) National Institutes of Health (U.S.) (P30-ES002109) 2017-05-24T19:59:44Z 2017-05-24T19:59:44Z 2015-02 2015-01 Article http://purl.org/eprint/type/JournalArticle 0008-5472 1538-7445 http://hdl.handle.net/1721.1/109330 Poutahidis, T. et al. “Dietary Microbes Modulate Transgenerational Cancer Risk.” Cancer Research 75.7 (2015): 1197–1204. https://orcid.org/0000-0002-8033-8380 https://orcid.org/0000-0001-8294-9364 en_US http://dx.doi.org/10.1158/0008-5472.can-14-2732 Cancer Research Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for Cancer Research PMC |
spellingShingle | Chatzigiagkos, A. Kearney, Sean M Alm, Eric J Poutahidis, Theofilos Varian, Bernard Urman, Tatiana Lakritz, Jessica Mirabal, Sheyla Kwok, Caitlin Ibrahim, Yassin M Erdman, Susan E Dietary Microbes Modulate Transgenerational Cancer Risk |
title | Dietary Microbes Modulate Transgenerational Cancer Risk |
title_full | Dietary Microbes Modulate Transgenerational Cancer Risk |
title_fullStr | Dietary Microbes Modulate Transgenerational Cancer Risk |
title_full_unstemmed | Dietary Microbes Modulate Transgenerational Cancer Risk |
title_short | Dietary Microbes Modulate Transgenerational Cancer Risk |
title_sort | dietary microbes modulate transgenerational cancer risk |
url | http://hdl.handle.net/1721.1/109330 https://orcid.org/0000-0002-8033-8380 https://orcid.org/0000-0001-8294-9364 |
work_keys_str_mv | AT chatzigiagkosa dietarymicrobesmodulatetransgenerationalcancerrisk AT kearneyseanm dietarymicrobesmodulatetransgenerationalcancerrisk AT almericj dietarymicrobesmodulatetransgenerationalcancerrisk AT poutahidistheofilos dietarymicrobesmodulatetransgenerationalcancerrisk AT varianbernard dietarymicrobesmodulatetransgenerationalcancerrisk AT urmantatiana dietarymicrobesmodulatetransgenerationalcancerrisk AT lakritzjessica dietarymicrobesmodulatetransgenerationalcancerrisk AT mirabalsheyla dietarymicrobesmodulatetransgenerationalcancerrisk AT kwokcaitlin dietarymicrobesmodulatetransgenerationalcancerrisk AT ibrahimyassinm dietarymicrobesmodulatetransgenerationalcancerrisk AT erdmansusane dietarymicrobesmodulatetransgenerationalcancerrisk |