Dietary Microbes Modulate Transgenerational Cancer Risk

Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary...

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Main Authors: Chatzigiagkos, A., Kearney, Sean M, Alm, Eric J, Poutahidis, Theofilos, Varian, Bernard, Urman, Tatiana, Lakritz, Jessica, Mirabal, Sheyla, Kwok, Caitlin, Ibrahim, Yassin M, Erdman, Susan E
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Association for Cancer Research 2017
Online Access:http://hdl.handle.net/1721.1/109330
https://orcid.org/0000-0002-8033-8380
https://orcid.org/0000-0001-8294-9364
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author Chatzigiagkos, A.
Kearney, Sean M
Alm, Eric J
Poutahidis, Theofilos
Varian, Bernard
Urman, Tatiana
Lakritz, Jessica
Mirabal, Sheyla
Kwok, Caitlin
Ibrahim, Yassin M
Erdman, Susan E
author2 Massachusetts Institute of Technology. Department of Biological Engineering
author_facet Massachusetts Institute of Technology. Department of Biological Engineering
Chatzigiagkos, A.
Kearney, Sean M
Alm, Eric J
Poutahidis, Theofilos
Varian, Bernard
Urman, Tatiana
Lakritz, Jessica
Mirabal, Sheyla
Kwok, Caitlin
Ibrahim, Yassin M
Erdman, Susan E
author_sort Chatzigiagkos, A.
collection MIT
description Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer.
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spelling mit-1721.1/1093302022-09-28T08:37:29Z Dietary Microbes Modulate Transgenerational Cancer Risk Chatzigiagkos, A. Kearney, Sean M Alm, Eric J Poutahidis, Theofilos Varian, Bernard Urman, Tatiana Lakritz, Jessica Mirabal, Sheyla Kwok, Caitlin Ibrahim, Yassin M Erdman, Susan E Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Division of Comparative Medicine Kearney, Sean M Alm, Eric J Poutahidis, Theofilos Varian, Bernard Urman, Tatiana Lakritz, Jessica Mirabal, Sheyla Kwok, Caitlin Ibrahim, Yassin M Erdman, Susan E Environmental factors are suspected in the increase of obesity and cancer in industrialized countries but are poorly understood. Here, we used animal models to test how future generations may be affected by Westernized diets. We discover long-term consequences of grandmothers' in utero dietary exposures, leading to high rates of obesity and frequent cancers of lung and liver in two subsequent generations of mice. Transgenerational effects were transplantable using diet-associated bacteria communities alone. Consequently, feeding of beneficial microbes was sufficient to lower transgenerational risk for cancer and obesity regardless of diet history. Targeting microbes may be a highly effective population-based approach to lower risk for cancer. National Institutes of Health (U.S.) (RO1CA108854) National Institutes of Health (U.S.) (U01 CA164337) National Institutes of Health (U.S.) (P30-ES002109) 2017-05-24T19:59:44Z 2017-05-24T19:59:44Z 2015-02 2015-01 Article http://purl.org/eprint/type/JournalArticle 0008-5472 1538-7445 http://hdl.handle.net/1721.1/109330 Poutahidis, T. et al. “Dietary Microbes Modulate Transgenerational Cancer Risk.” Cancer Research 75.7 (2015): 1197–1204. https://orcid.org/0000-0002-8033-8380 https://orcid.org/0000-0001-8294-9364 en_US http://dx.doi.org/10.1158/0008-5472.can-14-2732 Cancer Research Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for Cancer Research PMC
spellingShingle Chatzigiagkos, A.
Kearney, Sean M
Alm, Eric J
Poutahidis, Theofilos
Varian, Bernard
Urman, Tatiana
Lakritz, Jessica
Mirabal, Sheyla
Kwok, Caitlin
Ibrahim, Yassin M
Erdman, Susan E
Dietary Microbes Modulate Transgenerational Cancer Risk
title Dietary Microbes Modulate Transgenerational Cancer Risk
title_full Dietary Microbes Modulate Transgenerational Cancer Risk
title_fullStr Dietary Microbes Modulate Transgenerational Cancer Risk
title_full_unstemmed Dietary Microbes Modulate Transgenerational Cancer Risk
title_short Dietary Microbes Modulate Transgenerational Cancer Risk
title_sort dietary microbes modulate transgenerational cancer risk
url http://hdl.handle.net/1721.1/109330
https://orcid.org/0000-0002-8033-8380
https://orcid.org/0000-0001-8294-9364
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