Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms
available in PMC 2016 June 30
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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John Wiley & Sons, Inc.
2017
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| Online Access: | http://hdl.handle.net/1721.1/109344 https://orcid.org/0000-0001-8060-2607 |
| _version_ | 1826194996463665152 |
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| author | Rodal, Avital A. Del Signore, Steven J. Martin, Adam C |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Rodal, Avital A. Del Signore, Steven J. Martin, Adam C |
| author_sort | Rodal, Avital A. |
| collection | MIT |
| description | available in PMC 2016 June 30 |
| first_indexed | 2024-09-23T10:05:08Z |
| format | Article |
| id | mit-1721.1/109344 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:05:08Z |
| publishDate | 2017 |
| publisher | John Wiley & Sons, Inc. |
| record_format | dspace |
| spelling | mit-1721.1/1093442022-09-30T18:50:48Z Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms Rodal, Avital A. Del Signore, Steven J. Martin, Adam C Massachusetts Institute of Technology. Department of Biology Martin, Adam C available in PMC 2016 June 30 For the last 100 years, Drosophila melanogaster has been a powerhouse genetic system for understanding mechanisms of inheritance, development, and behavior in animals. In recent years, advances in imaging and genetic tools have led to Drosophila becoming one of the most effective systems for unlocking the subcellular functions of proteins (and particularly cytoskeletal proteins) in complex developmental settings. In this review, written for non-Drosophila experts, we will discuss critical technical advances that have enabled these cell biological insights, highlighting three examples of cytoskeletal discoveries that have arisen as a result: (1) regulation of Arp2/3 complex in myoblast fusion, (2) cooperation of the actin filament nucleators Spire and Cappuccino in establishment of oocyte polarity, and (3) coordination of supracellular myosin cables. These specific examples illustrate the unique power of Drosophila both to uncover new cytoskeletal structures and functions, and to place these discoveries in a broader in vivo context, providing insights that would have been impossible in a cell culture model or in vitro. Many of the cellular structures identified in Drosophila have clear counterparts in mammalian cells and tissues, and therefore elucidating cytoskeletal functions in Drosophila will be broadly applicable to other organisms. National Institutes of Health (U.S.) (NIH/NINDS (DP2 NS082127)) Pew Scholars Program in the Biomedical Sciences National Institutes of Health (U.S.) (NIH/NIGMS (R01-GM084947)) American Cancer Society (Research Scholar Award) 2017-05-25T16:29:28Z 2017-05-25T16:29:28Z 2015-05 2015-01 Article http://purl.org/eprint/type/JournalArticle 19493584 http://hdl.handle.net/1721.1/109344 Rodal, Avital A., Steven J. Del Signore, and Adam C. Martin. “Drosophilacomes of Age as a Model System for Understanding the Function of Cytoskeletal Proteins in Cells, Tissues, and Organisms.” Cytoskeleton 72, no. 5 (May 2015): 207–224. https://orcid.org/0000-0001-8060-2607 en_US http://dx.doi.org/10.1002/cm.21228 Cytoskeleton Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf John Wiley & Sons, Inc. PMC |
| spellingShingle | Rodal, Avital A. Del Signore, Steven J. Martin, Adam C Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms |
| title | Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms |
| title_full | Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms |
| title_fullStr | Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms |
| title_full_unstemmed | Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms |
| title_short | Drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells, tissues, and organisms |
| title_sort | drosophila comes of age as a model system for understanding the function of cytoskeletal proteins in cells tissues and organisms |
| url | http://hdl.handle.net/1721.1/109344 https://orcid.org/0000-0001-8060-2607 |
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