Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms
Bacterial and fungal pathogens cause a variety of infectious diseases and constitute a significant threat to public health. The human innate immune system represents the first line of defense against pathogenic microbes and employs a range of chemical artillery to combat these invaders. One importan...
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| Format: | Članak |
| Jezik: | en_US |
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American Chemical Society (ACS)
2017
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| Online pristup: | http://hdl.handle.net/1721.1/109378 https://orcid.org/0000-0002-6153-8803 |
| _version_ | 1826208937108570112 |
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| author | Brophy, Megan Brunjes Nolan, Elizabeth Marie |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Brophy, Megan Brunjes Nolan, Elizabeth Marie |
| author_sort | Brophy, Megan Brunjes |
| collection | MIT |
| description | Bacterial and fungal pathogens cause a variety of infectious diseases and constitute a significant threat to public health. The human innate immune system represents the first line of defense against pathogenic microbes and employs a range of chemical artillery to combat these invaders. One important mechanism of innate immunity is the sequestration of metal ions that are essential nutrients. Manganese is one nutrient that is required for many pathogens to establish an infective lifestyle. This review summarizes recent advances in the role of manganese in the host–pathogen interaction and highlights Mn(II) sequestration by neutrophil calprotectin as well as how bacterial acquisition and utilization of manganese enables pathogenesis. |
| first_indexed | 2024-09-23T14:14:40Z |
| format | Article |
| id | mit-1721.1/109378 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:14:40Z |
| publishDate | 2017 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1093782022-10-01T20:05:01Z Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms Brophy, Megan Brunjes Nolan, Elizabeth Marie Massachusetts Institute of Technology. Department of Chemistry Brophy, Megan Brunjes Nolan, Elizabeth Marie Bacterial and fungal pathogens cause a variety of infectious diseases and constitute a significant threat to public health. The human innate immune system represents the first line of defense against pathogenic microbes and employs a range of chemical artillery to combat these invaders. One important mechanism of innate immunity is the sequestration of metal ions that are essential nutrients. Manganese is one nutrient that is required for many pathogens to establish an infective lifestyle. This review summarizes recent advances in the role of manganese in the host–pathogen interaction and highlights Mn(II) sequestration by neutrophil calprotectin as well as how bacterial acquisition and utilization of manganese enables pathogenesis. Massachusetts Institute of Technology. Center for Environmental Health Sciences (NIH P30-ES002109) Kinship Foundation. Searle Scholars Program Massachusetts Institute of Technology. Department of Chemistry Alfred P. Sloan Foundation National Science Foundation (U.S.) (NSF CHE-1352132) National Institutes of Health (U.S.) (NIH Office of the Director Grant 1DP2OD007045) 2017-05-26T17:10:05Z 2017-05-26T17:10:05Z 2015-01 Article http://purl.org/eprint/type/JournalArticle 1554-8929 1554-8937 http://hdl.handle.net/1721.1/109378 Brophy, Megan Brunjes, and Elizabeth M. Nolan. “Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms.” ACS Chemical Biology 10, no. 3 (March 20, 2015): 641–651. © 2015 American Chemical Society. https://orcid.org/0000-0002-6153-8803 en_US http://dx.doi.org/10.1021/cb500792b ACS Chemical Biology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Brophy, Megan Brunjes Nolan, Elizabeth Marie Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms |
| title | Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms |
| title_full | Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms |
| title_fullStr | Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms |
| title_full_unstemmed | Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms |
| title_short | Manganese and Microbial Pathogenesis: Sequestration by the Mammalian Immune System and Utilization by Microorganisms |
| title_sort | manganese and microbial pathogenesis sequestration by the mammalian immune system and utilization by microorganisms |
| url | http://hdl.handle.net/1721.1/109378 https://orcid.org/0000-0002-6153-8803 |
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