Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study
The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful biomarkers of β-cell injury/dysfunction that would allow more accurate subtyping of diabetes. We measured plasma levels...
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| Format: | Article |
| Language: | en_US |
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Springer Nature
2017
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| Online Access: | http://hdl.handle.net/1721.1/109380 |
| _version_ | 1826204664901664768 |
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| author | Nunez Lopez, Yury O. Xie, Hui Yi, Fanchao Mathews, Clayton Pasarica, Magdalena Pratley, Richard E. Seyhan, Attila A |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Nunez Lopez, Yury O. Xie, Hui Yi, Fanchao Mathews, Clayton Pasarica, Magdalena Pratley, Richard E. Seyhan, Attila A |
| author_sort | Nunez Lopez, Yury O. |
| collection | MIT |
| description | The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful biomarkers of β-cell injury/dysfunction that would allow more accurate subtyping of diabetes. We measured plasma levels of selected miRNAs in subjects with prediabetes (n = 12), type 2 diabetes (T2D, n = 31), latent autoimmune diabetes of adults (LADA, n = 6) and type 1 diabetes (T1D, n = 16) and compared them to levels in healthy control subjects (n = 27). The study was conducted at the Translational Research Institute for Metabolism and Diabetes (TRI-MD), Florida Hospital. MiRNAs including miR-375 (linked to β-cell injury), miR-21 (associated with islet inflammation), miR-24.1, miR-30d, miR-34a, miR-126, miR-146, and miR-148a were significantly elevated in subjects with various forms of diabetes compared to healthy controls. Levels of several miRNAs were significantly correlated with glucose responses during oral glucose tolerance testing, HbA[subscript 1c], β-cell function, and insulin resistance in healthy controls, prediabetes, and T2D. These data suggest that miRNAs linked to β-cell injury and islet inflammation might be useful biomarkers to distinguish between subtypes of diabetes. This information could be used to predict progression of the disease, guide selection of optimal therapy and monitor responses to interventions, thus improving outcomes in patients with diabetes. |
| first_indexed | 2024-09-23T12:58:43Z |
| format | Article |
| id | mit-1721.1/109380 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:58:43Z |
| publishDate | 2017 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1093802022-10-01T12:19:48Z Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study Nunez Lopez, Yury O. Xie, Hui Yi, Fanchao Mathews, Clayton Pasarica, Magdalena Pratley, Richard E. Seyhan, Attila A Massachusetts Institute of Technology. Department of Chemical Engineering Seyhan, Attila A The clinical presentation of diabetes sometimes overlaps, contributing to ambiguity in the diagnosis. Thus, circulating pancreatic islet-enriched microRNAs (miRNAs) might be useful biomarkers of β-cell injury/dysfunction that would allow more accurate subtyping of diabetes. We measured plasma levels of selected miRNAs in subjects with prediabetes (n = 12), type 2 diabetes (T2D, n = 31), latent autoimmune diabetes of adults (LADA, n = 6) and type 1 diabetes (T1D, n = 16) and compared them to levels in healthy control subjects (n = 27). The study was conducted at the Translational Research Institute for Metabolism and Diabetes (TRI-MD), Florida Hospital. MiRNAs including miR-375 (linked to β-cell injury), miR-21 (associated with islet inflammation), miR-24.1, miR-30d, miR-34a, miR-126, miR-146, and miR-148a were significantly elevated in subjects with various forms of diabetes compared to healthy controls. Levels of several miRNAs were significantly correlated with glucose responses during oral glucose tolerance testing, HbA[subscript 1c], β-cell function, and insulin resistance in healthy controls, prediabetes, and T2D. These data suggest that miRNAs linked to β-cell injury and islet inflammation might be useful biomarkers to distinguish between subtypes of diabetes. This information could be used to predict progression of the disease, guide selection of optimal therapy and monitor responses to interventions, thus improving outcomes in patients with diabetes. Translational Research Institute for Metabolism and Diabetes (TRI) 2017-05-26T17:32:09Z 2017-05-26T17:32:09Z 2016-08 2015-06 Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/109380 Seyhan, Attila A., Yury O. Nunez Lopez, Hui Xie, Fanchao Yi, Clayton Mathews, Magdalena Pasarica, and Richard E. Pratley. “Pancreas-Enriched miRNAs Are Altered in the Circulation of Subjects with Diabetes: a Pilot Cross-Sectional Study.” Scientific Reports 6 (August 25, 2016): 31479. en_US http://dx.doi.org/10.1038/srep31479 Scientific Reports Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Springer Nature Nature |
| spellingShingle | Nunez Lopez, Yury O. Xie, Hui Yi, Fanchao Mathews, Clayton Pasarica, Magdalena Pratley, Richard E. Seyhan, Attila A Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study |
| title | Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study |
| title_full | Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study |
| title_fullStr | Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study |
| title_full_unstemmed | Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study |
| title_short | Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study |
| title_sort | pancreas enriched mirnas are altered in the circulation of subjects with diabetes a pilot cross sectional study |
| url | http://hdl.handle.net/1721.1/109380 |
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