A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4⁺ T-Cells to Recognition by Cytotoxic T-Lymphocytes

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4⁺ T-Cells to Recognition by Cytotoxic T-Lymphocytes

Resting CD4⁺ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic effects, nor are efficiently cleared by immune effectors. Elimination of this re...

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Bibliographic Details
Main Authors: O’Connor, Rachel, Rimpel, Katherine, Sloan, Derek D., Karel, Dan, Wong, Hing C., Jeng, Emily K., Thomas, Allison S., Whitney, James B., Lim, So-Yon, Kovacs, Colin, Benko, Erika, Karandish, Sara, Huang, Szu-Han, Buzon, Maria J., Lichterfeld, Mathias, Irrinki, Alivelu, Murry, Jeffrey P., Tsai, Angela, Yu, Helen, Geleziunas, Romas, Trocha, Alicja, Ostrowski, Mario A., Walker, Bruce D., Jones, Richard Bradley, Mueller, Stefanie, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/1721.1/109448
https://orcid.org/0000-0003-4083-335X

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