A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites

A new design for a green calcium indicator with a smaller size and a reduced number of calcium-binding sites

Genetically encoded calcium indicators (GECIs) are mainly represented by two- or one-fluorophore-based sensors. One type of two-fluorophore-based sensor, carrying Opsanus troponin C (TnC) as the Ca²⁺-binding moiety, has two binding sites for calcium ions, providing a linear response to calcium ions....

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Bibliographic Details
Main Authors: Barykina, Natalia V., Subach, Oksana M., Doronin, Danila A., Sotskov, Vladimir P., Roshchina, Marina A., Kunitsyna, Tatiana A., Malyshev, Aleksey Y., Smirnov, Ivan V., Azieva, Asya M., Sokolov, Ilya S., Burtsev, Mikhail S., Varizhuk, Anna M., Pozmogova, Galina E., Anokhin, Konstantin V., Subach, Fedor V., Enikolopov, Grigori N., Piatkevich, Kiryl
Other Authors: Massachusetts Institute of Technology. Media Laboratory
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/109457

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