Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging
Brillouin spectroscopy probes the mechanical properties of material by measuring the optical frequency shift induced by photon-phonon scattering interactions. In traditional configurations, Brillouin spectrometers measure only one point of the sample at a time. This results in long acquisition times...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/109467 |
| _version_ | 1811096705339228160 |
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| author | Zhang, Jitao Fiore, Antonio Kim, Hanyoup Scarcelli, Giuliano Yun, Seok Hyun (Andy) |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Zhang, Jitao Fiore, Antonio Kim, Hanyoup Scarcelli, Giuliano Yun, Seok Hyun (Andy) |
| author_sort | Zhang, Jitao |
| collection | MIT |
| description | Brillouin spectroscopy probes the mechanical properties of material by measuring the optical frequency shift induced by photon-phonon scattering interactions. In traditional configurations, Brillouin spectrometers measure only one point of the sample at a time. This results in long acquisition times for mechanical imaging of large areas. In this work, we demonstrate a parallel detection configuration where the Brillouin shift of hundreds of points in a line can be measured simultaneously. In mm-sized samples, this novel configuration effectively shortens the acquisition time of two-dimensional Brillouin imaging from hours to tens of seconds, thus making it a powerful technology for label-free mechanical characterization of tissue and biomaterials. |
| first_indexed | 2024-09-23T16:47:44Z |
| format | Article |
| id | mit-1721.1/109467 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:47:44Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1094672022-10-03T08:21:40Z Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging Zhang, Jitao Fiore, Antonio Kim, Hanyoup Scarcelli, Giuliano Yun, Seok Hyun (Andy) Harvard University--MIT Division of Health Sciences and Technology Yun, Seok Hyun (Andy) Brillouin spectroscopy probes the mechanical properties of material by measuring the optical frequency shift induced by photon-phonon scattering interactions. In traditional configurations, Brillouin spectrometers measure only one point of the sample at a time. This results in long acquisition times for mechanical imaging of large areas. In this work, we demonstrate a parallel detection configuration where the Brillouin shift of hundreds of points in a line can be measured simultaneously. In mm-sized samples, this novel configuration effectively shortens the acquisition time of two-dimensional Brillouin imaging from hours to tens of seconds, thus making it a powerful technology for label-free mechanical characterization of tissue and biomaterials. National Institutes of Health (U.S.) (K25EB015885) National Institutes of Health (U.S.) (R21EY023043) National Institutes of Health (U.S.) (R01EY025454) National Science Foundation (U.S.) (CMMI-1537027) National Science Foundation (U.S.) (CBET-0853773) Human Frontier Science Program (Strasbourg, France) (Young Investigator Grant) Canon Innovation Award 2017-05-31T16:23:25Z 2017-05-31T16:23:25Z 2016-10 2016-04 Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/109467 Zhang, Jitao, Antonio Fiore, Seok-Hyun Yun, Hanyoup Kim, and Giuliano Scarcelli. “Line-Scanning Brillouin Microscopy for Rapid Non-Invasive Mechanical Imaging.” Scientific Reports 6, no. 1 (October 14, 2016). en_US http://dx.doi.org/10.1038/srep35398 Scientific Reports Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature |
| spellingShingle | Zhang, Jitao Fiore, Antonio Kim, Hanyoup Scarcelli, Giuliano Yun, Seok Hyun (Andy) Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging |
| title | Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging |
| title_full | Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging |
| title_fullStr | Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging |
| title_full_unstemmed | Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging |
| title_short | Line-scanning Brillouin microscopy for rapid non-invasive mechanical imaging |
| title_sort | line scanning brillouin microscopy for rapid non invasive mechanical imaging |
| url | http://hdl.handle.net/1721.1/109467 |
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