BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the n...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Society for Neuroscience
2017
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| Online Access: | http://hdl.handle.net/1721.1/109606 https://orcid.org/0000-0002-3854-5968 |
| _version_ | 1826188988679979008 |
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| author | Sun, H. Martin, J. A. Werner, C. T. Wang, Z.-J. Damez-Werno, D. M. Scobie, K. N. Shao, N.-Y. Dias, C. Rabkin, J. Koo, J. W. Gancarz, A. M. Mouzon, E. A. Shen, L. Dietz, D. M. Nestler, E. J. Neve, Rachael L. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Sun, H. Martin, J. A. Werner, C. T. Wang, Z.-J. Damez-Werno, D. M. Scobie, K. N. Shao, N.-Y. Dias, C. Rabkin, J. Koo, J. W. Gancarz, A. M. Mouzon, E. A. Shen, L. Dietz, D. M. Nestler, E. J. Neve, Rachael L. |
| author_sort | Sun, H. |
| collection | MIT |
| description | ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (NAc), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. In contrast, no regulation is seen in mice that are susceptible to this chronic stress. Viral-mediated overexpression of Baz1b, along with its associated subunit Smarca5, in mouse NAc is sufficient to potentiate both rewarding responses to cocaine, including cocaine self-administration, and resilience to chronic social defeat stress. However, despite these similar, proreward behavioral effects, genome-wide mapping of BAZ1B in NAc revealed mostly distinct subsets of genes regulated by these chromatin remodeling proteins after chronic exposure to either cocaine or social stress. Together, these findings suggest important roles for BAZ1B and its associated chromatin remodeling complexes in NAc in the regulation of reward behaviors to distinct emotional stimuli and highlight the stimulus-specific nature of the actions of these regulatory proteins. |
| first_indexed | 2024-09-23T08:07:46Z |
| format | Article |
| id | mit-1721.1/109606 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:07:46Z |
| publishDate | 2017 |
| publisher | Society for Neuroscience |
| record_format | dspace |
| spelling | mit-1721.1/1096062022-09-23T11:07:35Z BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli Sun, H. Martin, J. A. Werner, C. T. Wang, Z.-J. Damez-Werno, D. M. Scobie, K. N. Shao, N.-Y. Dias, C. Rabkin, J. Koo, J. W. Gancarz, A. M. Mouzon, E. A. Shen, L. Dietz, D. M. Nestler, E. J. Neve, Rachael L. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Neve, Rachael L. ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate that Baz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (NAc), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. In contrast, no regulation is seen in mice that are susceptible to this chronic stress. Viral-mediated overexpression of Baz1b, along with its associated subunit Smarca5, in mouse NAc is sufficient to potentiate both rewarding responses to cocaine, including cocaine self-administration, and resilience to chronic social defeat stress. However, despite these similar, proreward behavioral effects, genome-wide mapping of BAZ1B in NAc revealed mostly distinct subsets of genes regulated by these chromatin remodeling proteins after chronic exposure to either cocaine or social stress. Together, these findings suggest important roles for BAZ1B and its associated chromatin remodeling complexes in NAc in the regulation of reward behaviors to distinct emotional stimuli and highlight the stimulus-specific nature of the actions of these regulatory proteins. 2017-06-05T19:25:32Z 2017-06-05T19:25:32Z 2016-04 2016-02 Article http://purl.org/eprint/type/JournalArticle 0270-6474 1529-2401 http://hdl.handle.net/1721.1/109606 Sun, H. et al. “BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli.” Journal of Neuroscience 36.14 (2016): 3954–3961. https://orcid.org/0000-0002-3854-5968 en_US http://dx.doi.org/10.1523/jneurosci.3254-15.2016 Journal of Neuroscience Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Society for Neuroscience Society for Neuroscience |
| spellingShingle | Sun, H. Martin, J. A. Werner, C. T. Wang, Z.-J. Damez-Werno, D. M. Scobie, K. N. Shao, N.-Y. Dias, C. Rabkin, J. Koo, J. W. Gancarz, A. M. Mouzon, E. A. Shen, L. Dietz, D. M. Nestler, E. J. Neve, Rachael L. BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli |
| title | BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli |
| title_full | BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli |
| title_fullStr | BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli |
| title_full_unstemmed | BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli |
| title_short | BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli |
| title_sort | baz1b in nucleus accumbens regulates reward related behaviors in response to distinct emotional stimuli |
| url | http://hdl.handle.net/1721.1/109606 https://orcid.org/0000-0002-3854-5968 |
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