Memory engram storage and retrieval
A great deal of experimental investment is directed towards questions regarding the mechanisms of memory storage. Such studies have traditionally been restricted to investigation of the anatomical structures, physiological processes, and molecular pathways necessary for the capacity of memory storag...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/109777 https://orcid.org/0000-0003-2839-8228 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-0121-8514 |
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| author | Tonegawa, Susumu Pignatelli di Spinazzola, Michele Roy, Dheeraj Ryan, Tomas John |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Tonegawa, Susumu Pignatelli di Spinazzola, Michele Roy, Dheeraj Ryan, Tomas John |
| author_sort | Tonegawa, Susumu |
| collection | MIT |
| description | A great deal of experimental investment is directed towards questions regarding the mechanisms of memory storage. Such studies have traditionally been restricted to investigation of the anatomical structures, physiological processes, and molecular pathways necessary for the capacity of memory storage, and have avoided the question of how individual memories are stored in the brain. Memory engram technology allows the labeling and subsequent manipulation of components of specific memory engrams in particular brain regions, and it has been established that cell ensembles labeled by this method are both sufficient and necessary for memory recall. Recent research has employed this technology to probe fundamental questions of memory consolidation, differentiating between mechanisms of memory retrieval and the true neurobiology of memory storage. |
| first_indexed | 2024-09-23T15:16:29Z |
| format | Article |
| id | mit-1721.1/109777 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:16:29Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1097772022-09-29T13:49:55Z Memory engram storage and retrieval Tonegawa, Susumu Pignatelli di Spinazzola, Michele Roy, Dheeraj Ryan, Tomas John Picower Institute for Learning and Memory Tonegawa, Susumu Pignatelli di Spinazzola, Michele Roy, Dheeraj Ryan, Tomas John A great deal of experimental investment is directed towards questions regarding the mechanisms of memory storage. Such studies have traditionally been restricted to investigation of the anatomical structures, physiological processes, and molecular pathways necessary for the capacity of memory storage, and have avoided the question of how individual memories are stored in the brain. Memory engram technology allows the labeling and subsequent manipulation of components of specific memory engrams in particular brain regions, and it has been established that cell ensembles labeled by this method are both sufficient and necessary for memory recall. Recent research has employed this technology to probe fundamental questions of memory consolidation, differentiating between mechanisms of memory retrieval and the true neurobiology of memory storage. 2017-06-09T19:22:17Z 2017-06-09T19:22:17Z 2015-08 Article http://purl.org/eprint/type/JournalArticle 0959-4388 http://hdl.handle.net/1721.1/109777 Tonegawa, Susumu, Michele Pignatelli, Dheeraj S Roy, and Tomás J Ryan. “Memory Engram Storage and Retrieval.” Current Opinion in Neurobiology 35 (December 2015): 101–109 © 2015 The Authors https://orcid.org/0000-0003-2839-8228 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-0121-8514 en_US http://dx.doi.org/10.1016/j.conb.2015.07.009 Current Opinion in Neurobiology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Tonegawa, Susumu Pignatelli di Spinazzola, Michele Roy, Dheeraj Ryan, Tomas John Memory engram storage and retrieval |
| title | Memory engram storage and retrieval |
| title_full | Memory engram storage and retrieval |
| title_fullStr | Memory engram storage and retrieval |
| title_full_unstemmed | Memory engram storage and retrieval |
| title_short | Memory engram storage and retrieval |
| title_sort | memory engram storage and retrieval |
| url | http://hdl.handle.net/1721.1/109777 https://orcid.org/0000-0003-2839-8228 https://orcid.org/0000-0002-5218-1216 https://orcid.org/0000-0003-0121-8514 |
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