Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in
Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of Caenorhabditis elegans is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. Here, we show that C. elegans...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
eLife Sciences Publications, Ltd.
2017
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| Online Access: | http://hdl.handle.net/1721.1/109869 https://orcid.org/0000-0002-3833-6912 https://orcid.org/0000-0002-4109-5152 |
| _version_ | 1826205837611237376 |
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| author | Hilbert, Zoe Alyse Kim, Dennis H. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hilbert, Zoe Alyse Kim, Dennis H. |
| author_sort | Hilbert, Zoe Alyse |
| collection | MIT |
| description | Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of Caenorhabditis elegans is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs—sex, age, nutritional status, and microbial environment—which function in the modulation of behavior. Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans. |
| first_indexed | 2024-09-23T13:19:54Z |
| format | Article |
| id | mit-1721.1/109869 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:19:54Z |
| publishDate | 2017 |
| publisher | eLife Sciences Publications, Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/1098692022-09-28T13:28:06Z Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in Hilbert, Zoe Alyse Kim, Dennis H. Massachusetts Institute of Technology. Department of Biology Hilbert, Zoe Alyse Kim, Dennis H. Animal behavior is directed by the integration of sensory information from internal states and the environment. Neuroendocrine regulation of diverse behaviors of Caenorhabditis elegans is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs—sex, age, nutritional status, and microbial environment—which function in the modulation of behavior. Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans. United States. National Institutes of Health (GM084477) 2017-06-14T19:56:04Z 2017-06-14T19:56:04Z 2017-01 2016-09 Article http://purl.org/eprint/type/JournalArticle 2050-084X http://hdl.handle.net/1721.1/109869 Hilbert, Zoë A, and Kim, Dennis H. “Sexually Dimorphic Control of Gene Expression in Sensory Neurons Regulates Decision-Making Behavior in C. Elegans.” eLife 6 (January 2017): e21166 © 2017 Hilbert et al https://orcid.org/0000-0002-3833-6912 https://orcid.org/0000-0002-4109-5152 en_US http://dx.doi.org/10.7554/eLife.21166 eLife Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf eLife Sciences Publications, Ltd. eLife |
| spellingShingle | Hilbert, Zoe Alyse Kim, Dennis H. Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in |
| title | Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in |
| title_full | Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in |
| title_fullStr | Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in |
| title_full_unstemmed | Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in |
| title_short | Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in |
| title_sort | sexually dimorphic control of gene expression in sensory neurons regulates decision making behavior in |
| url | http://hdl.handle.net/1721.1/109869 https://orcid.org/0000-0002-3833-6912 https://orcid.org/0000-0002-4109-5152 |
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