Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility
Purpose: Evaluation of the effect of prelaminar tissue thickness on visualization of the lamina cribrosa (LC) using optical coherence tomography (OCT). Methods: The optic nerve head (ONH) region was scanned using OCT. The quality of visible LC microstructure was assessed subjectively using a grad...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Association for Research in Vision and Ophthalmology
2017
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| Online Access: | http://hdl.handle.net/1721.1/109904 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1826195016742076416 |
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| author | Lucy, Katie A. Wang, Bo Schuman, Joel S. Bilonick, Richard A. Ling, Yun Kagemann, Larry Sigal, Ian A. Ishikawa, Hiroshi Wollstein, Gadi Liu, Jonathan Jaoshin Fujimoto, James G Grulkowski, Ireneusz |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Lucy, Katie A. Wang, Bo Schuman, Joel S. Bilonick, Richard A. Ling, Yun Kagemann, Larry Sigal, Ian A. Ishikawa, Hiroshi Wollstein, Gadi Liu, Jonathan Jaoshin Fujimoto, James G Grulkowski, Ireneusz |
| author_sort | Lucy, Katie A. |
| collection | MIT |
| description | Purpose: Evaluation of the effect of prelaminar tissue thickness on visualization of the lamina cribrosa (LC) using optical coherence tomography (OCT).
Methods: The optic nerve head (ONH) region was scanned using OCT. The quality of visible LC microstructure was assessed subjectively using a grading system and objectively by analyzing the signal intensity of each scan's superpixel components. Manual delineations were made separately and in 3-dimensions quantifying prelaminar tissue thickness, analyzable regions of LC microstructure, and regions with a visible anterior LC (ALC) boundary. A linear mixed effect model quantified the association between tissue thickness and LC visualization.
Results: A total of 17 healthy, 27 glaucoma suspect, and 47 glaucomatous eyes were included. Scans with thicker average prelaminar tissue measurements received worse grading scores (P = 0.007), and superpixels with low signal intensity were associated significantly with regions beneath thick prelaminar tissue (P < 0.05). The average prelaminar tissue thickness in regions of scans where the LC was analyzable (214 μm) was significantly thinner than in regions where the LC was not analyzable (569 μm; P < 0.001). Healthy eyes had significantly thicker average prelaminar tissue measurements than glaucoma or glaucoma suspect eyes (both P < 0.001), and glaucoma suspect eyes had significantly thicker average prelaminar tissue measurements than glaucoma eyes (P = 0.008). Significantly more of the ALC boundary was visible in glaucoma eyes (63% of ONH) than in healthy eyes (41%; P = 0.005).
Conclusions: Thick prelaminar tissue was associated with impaired visualization of the LC. Healthy subjects generally had thicker prelaminar tissue, which potentially could create a selection bias against healthy eyes when comparing LC structures. |
| first_indexed | 2024-09-23T10:05:26Z |
| format | Article |
| id | mit-1721.1/109904 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:05:26Z |
| publishDate | 2017 |
| publisher | Association for Research in Vision and Ophthalmology |
| record_format | dspace |
| spelling | mit-1721.1/1099042022-09-30T18:54:41Z Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility Lucy, Katie A. Wang, Bo Schuman, Joel S. Bilonick, Richard A. Ling, Yun Kagemann, Larry Sigal, Ian A. Ishikawa, Hiroshi Wollstein, Gadi Liu, Jonathan Jaoshin Fujimoto, James G Grulkowski, Ireneusz Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Liu, Jonathan Jaoshin Fujimoto, James G Grulkowski, Ireneusz Purpose: Evaluation of the effect of prelaminar tissue thickness on visualization of the lamina cribrosa (LC) using optical coherence tomography (OCT). Methods: The optic nerve head (ONH) region was scanned using OCT. The quality of visible LC microstructure was assessed subjectively using a grading system and objectively by analyzing the signal intensity of each scan's superpixel components. Manual delineations were made separately and in 3-dimensions quantifying prelaminar tissue thickness, analyzable regions of LC microstructure, and regions with a visible anterior LC (ALC) boundary. A linear mixed effect model quantified the association between tissue thickness and LC visualization. Results: A total of 17 healthy, 27 glaucoma suspect, and 47 glaucomatous eyes were included. Scans with thicker average prelaminar tissue measurements received worse grading scores (P = 0.007), and superpixels with low signal intensity were associated significantly with regions beneath thick prelaminar tissue (P < 0.05). The average prelaminar tissue thickness in regions of scans where the LC was analyzable (214 μm) was significantly thinner than in regions where the LC was not analyzable (569 μm; P < 0.001). Healthy eyes had significantly thicker average prelaminar tissue measurements than glaucoma or glaucoma suspect eyes (both P < 0.001), and glaucoma suspect eyes had significantly thicker average prelaminar tissue measurements than glaucoma eyes (P = 0.008). Significantly more of the ALC boundary was visible in glaucoma eyes (63% of ONH) than in healthy eyes (41%; P = 0.005). Conclusions: Thick prelaminar tissue was associated with impaired visualization of the LC. Healthy subjects generally had thicker prelaminar tissue, which potentially could create a selection bias against healthy eyes when comparing LC structures. United States. National Institutes of Health (R01-EY013178) United States. National Institutes of Health (R01-EY025011) United States. National Institutes of Health (R01-EY011289) United States. National Institutes of Health (P30-EY008098) United States. National Institutes of Health (T32-EY017271) 2017-06-15T18:34:04Z 2017-06-15T18:34:04Z 2017-03 Article http://purl.org/eprint/type/JournalArticle 1552-5783 http://hdl.handle.net/1721.1/109904 Lucy, Katie A.; Wang, Bo; Schuman, Joel S.; Bilonick, Richard A.; Ling, Yun; Kagemann, Larry; Sigal, Ian A. et al. “Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility.” Investigative Opthalmology & Visual Science 58, no. 3 (March 2017): 1751 © 2017 The Authors https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1167/iovs.16-20784 Investigative Opthalmology & Visual Science Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Association for Research in Vision and Ophthalmology Association for Research in Vision and Ophthalmology (ARVO) |
| spellingShingle | Lucy, Katie A. Wang, Bo Schuman, Joel S. Bilonick, Richard A. Ling, Yun Kagemann, Larry Sigal, Ian A. Ishikawa, Hiroshi Wollstein, Gadi Liu, Jonathan Jaoshin Fujimoto, James G Grulkowski, Ireneusz Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility |
| title | Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility |
| title_full | Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility |
| title_fullStr | Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility |
| title_full_unstemmed | Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility |
| title_short | Thick Prelaminar Tissue Decreases Lamina Cribrosa Visibility |
| title_sort | thick prelaminar tissue decreases lamina cribrosa visibility |
| url | http://hdl.handle.net/1721.1/109904 https://orcid.org/0000-0002-0828-4357 |
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