Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons
Feature-selective firing allows networks to produce representations of the external and internal environments. Despite its importance, the mechanisms generating neuronal feature selectivity are incompletely understood. In many cortical microcircuits the integration of two functionally distinct input...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/109917 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1811079982616674304 |
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| author | Bittner, Katie C Grienberger, Christine Vaidya, Sachin P Milstein, Aaron D Macklin, John J Magee, Jeffrey C Suh, Junghyup Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bittner, Katie C Grienberger, Christine Vaidya, Sachin P Milstein, Aaron D Macklin, John J Magee, Jeffrey C Suh, Junghyup Tonegawa, Susumu |
| author_sort | Bittner, Katie C |
| collection | MIT |
| description | Feature-selective firing allows networks to produce representations of the external and internal environments. Despite its importance, the mechanisms generating neuronal feature selectivity are incompletely understood. In many cortical microcircuits the integration of two functionally distinct inputs occurs nonlinearly through generation of active dendritic signals that drive burst firing and robust plasticity. To examine the role of this processing in feature selectivity, we recorded CA1 pyramidal neuron membrane potential and local field potential in mice running on a linear treadmill. We found that dendritic plateau potentials were produced by an interaction between properly timed input from entorhinal cortex and hippocampal CA3. These conjunctive signals positively modulated the firing of previously established place fields and rapidly induced new place field formation to produce feature selectivity in CA1 that is a function of both entorhinal cortex and CA3 input. Such selectivity could allow mixed network level representations that support context-dependent spatial maps. |
| first_indexed | 2024-09-23T11:23:36Z |
| format | Article |
| id | mit-1721.1/109917 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:23:36Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1099172022-09-27T19:16:23Z Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons Bittner, Katie C Grienberger, Christine Vaidya, Sachin P Milstein, Aaron D Macklin, John J Magee, Jeffrey C Suh, Junghyup Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Suh, Junghyup Tonegawa, Susumu Feature-selective firing allows networks to produce representations of the external and internal environments. Despite its importance, the mechanisms generating neuronal feature selectivity are incompletely understood. In many cortical microcircuits the integration of two functionally distinct inputs occurs nonlinearly through generation of active dendritic signals that drive burst firing and robust plasticity. To examine the role of this processing in feature selectivity, we recorded CA1 pyramidal neuron membrane potential and local field potential in mice running on a linear treadmill. We found that dendritic plateau potentials were produced by an interaction between properly timed input from entorhinal cortex and hippocampal CA3. These conjunctive signals positively modulated the firing of previously established place fields and rapidly induced new place field formation to produce feature selectivity in CA1 that is a function of both entorhinal cortex and CA3 input. Such selectivity could allow mixed network level representations that support context-dependent spatial maps. Howard Hughes Medical Institute Rikagaku Kenkyūjo (Japan) 2017-06-15T19:53:17Z 2017-06-15T19:53:17Z 2015-08 2015-05 Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/109917 Bittner, Katie C, Christine Grienberger, Sachin P Vaidya, Aaron D Milstein, John J Macklin, Junghyup Suh, Susumu Tonegawa, and Jeffrey C Magee. “Conjunctive Input Processing Drives Feature Selectivity in Hippocampal CA1 Neurons.” Nature Neuroscience 18, no. 8 (July 13, 2015): 1133–1142. https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1038/nn.4062 Nature Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Bittner, Katie C Grienberger, Christine Vaidya, Sachin P Milstein, Aaron D Macklin, John J Magee, Jeffrey C Suh, Junghyup Tonegawa, Susumu Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons |
| title | Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons |
| title_full | Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons |
| title_fullStr | Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons |
| title_full_unstemmed | Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons |
| title_short | Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons |
| title_sort | conjunctive input processing drives feature selectivity in hippocampal ca1 neurons |
| url | http://hdl.handle.net/1721.1/109917 https://orcid.org/0000-0003-2839-8228 |
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