Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway

Proteasomal degradation of topoisomerase I (topoI) is one of the most remarkable cellular phenomena observed in response to camptothecin (CPT). Importantly, the rate of topoI degradation is linked to CPT resistance. Formation of the topoI-DNA-CPT cleavable complex inhibits DNA re-ligation resulting...

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Bibliographic Details
Main Authors:	Ando, Koji, Shah, Ankur K., Sachdev, Vibhu, Kleinstiver, Benjamin P., Taylor-Parker, Julian, Welch, Moira M., Hu, Yiheng, Salgia, Ravi, Parvin, Jeffrey D., Ozonoff, Al, Rameh, Lucia E., Joung, J. Keith, Bharti, Ajit K., White, Forest M.
Other Authors:	Massachusetts Institute of Technology. Department of Biological Engineering
Format:	Article
Language:	en_US
Published:	Impact Journals/National Center for Biotechnology Information (U.S.) 2017
Online Access:	http://hdl.handle.net/1721.1/109949 https://orcid.org/0000-0002-1545-1651

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