Potent and Specific Peptide Inhibitors of Human Pro-Survival Protein Bcl-xL

The Bcl-2 family of proteins plays a critical role regulating apoptosis, and pro-survival Bcl-2 family members are important therapeutic targets due to their overexpression in different cancers. Pro-apoptotic Bcl-2 homology 3 (BH3)-only proteins antagonize pro-survival Bcl-2 protein functions by bin...

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Bibliographic Details
Main Authors: Ryan, Jeremy, Letai, Anthony, Dutta, Sanjib, Chen, T. Scott, Kougentakis, Christos, Keating, Amy E.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/109994
https://orcid.org/0000-0003-4074-8980