The Development, Commercialization, and Impact of Optical Coherence Tomography
This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure...
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| Format: | Article |
| Language: | en_US |
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Association for Research in Vision and Ophthalmology
2017
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| Online Access: | http://hdl.handle.net/1721.1/109995 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1811082935711825920 |
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| author | Fujimoto, James G Swanson, Eric A |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Fujimoto, James G Swanson, Eric A |
| author_sort | Fujimoto, James G |
| collection | MIT |
| description | This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an “ecosystem” consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact – all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest. |
| first_indexed | 2024-09-23T12:14:14Z |
| format | Article |
| id | mit-1721.1/109995 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:14:14Z |
| publishDate | 2017 |
| publisher | Association for Research in Vision and Ophthalmology |
| record_format | dspace |
| spelling | mit-1721.1/1099952022-10-01T08:47:18Z The Development, Commercialization, and Impact of Optical Coherence Tomography Fujimoto, James G Swanson, Eric A Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Fujimoto, James G Swanson, Eric A This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration and expertise. Optical coherence tomography had its origin in femtosecond optics, but used optical communications technologies and required advanced engineering for early OCT prototypes, clinical feasibility studies, entrepreneurship, and corporate development in order to achieve clinical acceptance and clinical impact. Critical advances were made by early career researchers, clinician scientists, engineering experts, and business leaders, which enabled OCT to have a worldwide impact on health care. We introduce the concept of an “ecosystem” consisting of research, government funding, collaboration and competition, clinical studies, innovation, entrepreneurship and industry, and impact – all of which must work synergistically. The process that we recount is long and challenging, but it is our hope that it might inspire early career professionals in science, engineering, and medicine, and that the clinical and research community will find this review of interest. National Institutes of Health (U.S.) (R01- EY11289) National Institutes of Health (U.S.) (R01-CA75289) National Institutes of Health (U.S.) (R01-CA178636) United States. Air Force. Office of Scientific Research (FA9550-10-1-0551) United States. Air Force. Office of Scientific Research (FA9550-12-1-0499) 2017-06-16T22:45:03Z 2017-06-16T22:45:03Z 2016-07 2016-05 Article http://purl.org/eprint/type/JournalArticle 1552-5783 http://hdl.handle.net/1721.1/109995 Fujimoto, James, and Eric Swanson. “The Development, Commercialization, and Impact of Optical Coherence Tomography.” Investigative Opthalmology & Visual Science 57, no. 9 (July 13, 2016): OCT1. https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1167/iovs.16-19963 Investigative Opthalmology & Visual Science Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Association for Research in Vision and Ophthalmology Association for Research in Vision and Ophthalmology (ARVO) |
| spellingShingle | Fujimoto, James G Swanson, Eric A The Development, Commercialization, and Impact of Optical Coherence Tomography |
| title | The Development, Commercialization, and Impact of Optical Coherence Tomography |
| title_full | The Development, Commercialization, and Impact of Optical Coherence Tomography |
| title_fullStr | The Development, Commercialization, and Impact of Optical Coherence Tomography |
| title_full_unstemmed | The Development, Commercialization, and Impact of Optical Coherence Tomography |
| title_short | The Development, Commercialization, and Impact of Optical Coherence Tomography |
| title_sort | development commercialization and impact of optical coherence tomography |
| url | http://hdl.handle.net/1721.1/109995 https://orcid.org/0000-0002-0828-4357 |
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