Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation
Mechanical forces in the cell’s natural environment have a crucial impact on growth, differentiation and behaviour. Few areas of biology can be understood without taking into account how both individual cells and cell networks sense and transduce physical stresses. However, the field is currently he...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/110124 https://orcid.org/0000-0001-7395-8824 |
| _version_ | 1826189253084708864 |
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| author | Sutton, Amy Shirman, Tanya Timonen, Jaakko V. I. England, Grant T Kim, Philseok Kolle, Mathias Ferrante, Thomas Zarzar, Lauren D Strong, Elizabeth Aizenberg, Joanna |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Sutton, Amy Shirman, Tanya Timonen, Jaakko V. I. England, Grant T Kim, Philseok Kolle, Mathias Ferrante, Thomas Zarzar, Lauren D Strong, Elizabeth Aizenberg, Joanna |
| author_sort | Sutton, Amy |
| collection | MIT |
| description | Mechanical forces in the cell’s natural environment have a crucial impact on growth, differentiation and behaviour. Few areas of biology can be understood without taking into account how both individual cells and cell networks sense and transduce physical stresses. However, the field is currently held back by the limitations of the available methods to apply physiologically relevant stress profiles on cells, particularly with sub-cellular resolution, in controlled in vitro experiments. Here we report a new type of active cell culture material that allows highly localized, directional and reversible deformation of the cell growth substrate, with control at scales ranging from the entire surface to the subcellular, and response times on the order of seconds. These capabilities are not matched by any other method, and this versatile material has the potential to bridge the performance gap between the existing single cell micro-manipulation and 2D cell sheet mechanical stimulation techniques. |
| first_indexed | 2024-09-23T08:12:12Z |
| format | Article |
| id | mit-1721.1/110124 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:12:12Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1101242022-09-30T08:16:47Z Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation Sutton, Amy Shirman, Tanya Timonen, Jaakko V. I. England, Grant T Kim, Philseok Kolle, Mathias Ferrante, Thomas Zarzar, Lauren D Strong, Elizabeth Aizenberg, Joanna Massachusetts Institute of Technology. Department of Mechanical Engineering Kolle, Mathias Mechanical forces in the cell’s natural environment have a crucial impact on growth, differentiation and behaviour. Few areas of biology can be understood without taking into account how both individual cells and cell networks sense and transduce physical stresses. However, the field is currently held back by the limitations of the available methods to apply physiologically relevant stress profiles on cells, particularly with sub-cellular resolution, in controlled in vitro experiments. Here we report a new type of active cell culture material that allows highly localized, directional and reversible deformation of the cell growth substrate, with control at scales ranging from the entire surface to the subcellular, and response times on the order of seconds. These capabilities are not matched by any other method, and this versatile material has the potential to bridge the performance gap between the existing single cell micro-manipulation and 2D cell sheet mechanical stimulation techniques. United States. Department of Energy (DE-SC0005247) United States. Office of Naval Research (N00014-15-1-2157) 2017-06-21T15:47:40Z 2017-06-21T15:47:40Z 2017-03 2016-04 Article http://purl.org/eprint/type/JournalArticle 2041-1723 http://hdl.handle.net/1721.1/110124 Sutton, Amy; Shirman, Tanya; Timonen, Jaakko V. I.; England, Grant T; Kim, Philseok; Kolle, Mathias; Ferrante, Thomas; Zarzar, Lauren D; Strong, Elizabeth and Aizenberg, Joanna. “Photothermally Triggered Actuation of Hybrid Materials as a New Platform for in Vitro Cell Manipulation.” Nature Communications 8 (March 2017): 14700 © 2017 The Authors https://orcid.org/0000-0001-7395-8824 en_US http://dx.doi.org/10.1038/ncomms14700 Nature Communications Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature |
| spellingShingle | Sutton, Amy Shirman, Tanya Timonen, Jaakko V. I. England, Grant T Kim, Philseok Kolle, Mathias Ferrante, Thomas Zarzar, Lauren D Strong, Elizabeth Aizenberg, Joanna Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation |
| title | Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation |
| title_full | Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation |
| title_fullStr | Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation |
| title_full_unstemmed | Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation |
| title_short | Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation |
| title_sort | photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation |
| url | http://hdl.handle.net/1721.1/110124 https://orcid.org/0000-0001-7395-8824 |
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